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Yanai Duran
Researcher at UCL Institute of Ophthalmology
Publications - 40
Citations - 3610
Yanai Duran is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Retina & Retinal degeneration. The author has an hindex of 25, co-authored 40 publications receiving 3177 citations. Previous affiliations of Yanai Duran include University College London.
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Journal ArticleDOI
Effective gene therapy with nonintegrating lentiviral vectors
Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Kamaljit S. Balaggan,A MacNeil,Steven J. Howe,Manfred Schmidt,Manfred Schmidt,Alexander J. Smith,Prateek K. Buch,Robert E MacLaren,Patrick N. Anderson,S. E. Barker,Yanai Duran,CC Bartholomae,CC Bartholomae,Christof von Kalle,John R. Heckenlively,Christine Kinnon,Robin R. Ali,Adrian J. Thrasher +20 more
TL;DR: The high efficiency of gene transfer and expression mediated by lentiviruses can be harnessed in vivo without a requirement for vector integration and substantially reduces the risk of insertional mutagenesis.
Journal ArticleDOI
Restoration of vision after transplantation of photoreceptors
Rachael A. Pearson,Amanda C. Barber,Matteo Rizzi,Claire Hippert,Tian Xue,Emma L. West,Yanai Duran,Alexander J. Smith,Jen-Zen Chuang,Selina A. Azam,Ulrich F O Luhmann,Andrea Benucci,Ching-Hwa Sung,James W B Bainbridge,Matteo Carandini,King Wai Yau,Jane C. Sowden,Robin R. Ali,Robin R. Ali +18 more
TL;DR: Evidence of functional rod-mediated vision after photoreceptor transplantation in adult Gnat1−/− mice is provided and it is demonstrated that visual signals generated by transplanted rods are projected to higher visual areas, including V1.
Journal ArticleDOI
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina
Anai Gonzalez-Cordero,Emma L. West,Rachael A. Pearson,Yanai Duran,Livia S. Carvalho,Colin J Chu,Arifa Naeem,Samuel J.I. Blackford,Anastasios Georgiadis,Jorn Lakowski,Mike Hubank,Alexander J. Smith,James W B Bainbridge,Jane C. Sowden,Robin R. Ali,Robin R. Ali +15 more
TL;DR: This study shows conclusively that ESCs can provide a source of photoreceptors for retinal cell transplantation and adapted a recently reported three-dimensional differentiation protocol that generates neuroretina from mouse ESCs to isolate photoreceptor precursors fit for transplantation.
Journal ArticleDOI
Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors.
Rachael A. Pearson,Anai Gonzalez-Cordero,Emma L. West,J. R. Ribeiro,Nozie D. Aghaizu,Debbie Goh,Robert D. Sampson,Anastasios Georgiadis,P. V. Waldron,Yanai Duran,Arifa Naeem,Magdalena Kloc,E. Cristante,Kamil Kruczek,Katherine Warre-Cornish,Jane C. Sowden,Andrew Smith,Robin R. Ali,Robin R. Ali +18 more
TL;DR: It is shown that while integration occurs the majority of donor-reporter-labelled cells in the host arises as a result of material transfer between donor and host photoreceptors, raising the possibility of materialtransfer as a strategy for the treatment of retinal disorders.
Journal ArticleDOI
Repair of the degenerate retina by photoreceptor transplantation
Amanda C. Barber,Claire Hippert,Yanai Duran,Emma L. West,James W B Bainbridge,Katherine Warre-Cornish,Ulrich F O Luhmann,Jorn Lakowski,Jane C. Sowden,Robin R. Ali,Rachael A. Pearson +10 more
TL;DR: It is possible to achieve robust integration across a broad range of inherited retinopathies, even in late-stage disease, and transplantation outcome can be improved by administering appropriate, tailored manipulations of the recipient environment.