R
Rachael A. Pearson
Researcher at University College London
Publications - 59
Citations - 5564
Rachael A. Pearson is an academic researcher from University College London. The author has contributed to research in topics: Retina & Transplantation. The author has an hindex of 33, co-authored 56 publications receiving 4926 citations. Previous affiliations of Rachael A. Pearson include King's College London & UCL Institute of Child Health.
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Journal ArticleDOI
Retinal Repair by Transplantation of Photoreceptor Precursors
Robert E MacLaren,Rachael A. Pearson,A MacNeil,Ronald H. Douglas,Thomas E. Salt,Masayuki Akimoto,Anand Swaroop,Jane C. Sowden,Robin R. Ali +8 more
TL;DR: It is shown that donor cells can integrate into the adult or degenerating retina if they are taken from the developing retina at a time coincident with the peak of rod genesis, and the ontogenetic stage of donor cells for successful rod photoreceptor transplantation is defined.
Journal ArticleDOI
Restoration of vision after transplantation of photoreceptors
Rachael A. Pearson,Amanda C. Barber,Matteo Rizzi,Claire Hippert,Tian Xue,Emma L. West,Yanai Duran,Alexander J. Smith,Jen-Zen Chuang,Selina A. Azam,Ulrich F O Luhmann,Andrea Benucci,Ching-Hwa Sung,James W B Bainbridge,Matteo Carandini,King Wai Yau,Jane C. Sowden,Robin R. Ali,Robin R. Ali +18 more
TL;DR: Evidence of functional rod-mediated vision after photoreceptor transplantation in adult Gnat1−/− mice is provided and it is demonstrated that visual signals generated by transplanted rods are projected to higher visual areas, including V1.
Journal ArticleDOI
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina
Anai Gonzalez-Cordero,Emma L. West,Rachael A. Pearson,Yanai Duran,Livia S. Carvalho,Colin J Chu,Arifa Naeem,Samuel J.I. Blackford,Anastasios Georgiadis,Jorn Lakowski,Mike Hubank,Alexander J. Smith,James W B Bainbridge,Jane C. Sowden,Robin R. Ali,Robin R. Ali +15 more
TL;DR: This study shows conclusively that ESCs can provide a source of photoreceptors for retinal cell transplantation and adapted a recently reported three-dimensional differentiation protocol that generates neuroretina from mouse ESCs to isolate photoreceptor precursors fit for transplantation.
Journal ArticleDOI
ATP Released via Gap Junction Hemichannels from the Pigment Epithelium Regulates Neural Retinal Progenitor Proliferation
TL;DR: It is shown that the RPE regulates proliferation in the underlying neural retina by the release of a soluble factor and identifies that factor as ATP, which speeds both cell division and proliferation inThe neural retina.
Journal ArticleDOI
Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors.
Rachael A. Pearson,Anai Gonzalez-Cordero,Emma L. West,J. R. Ribeiro,Nozie D. Aghaizu,Debbie Goh,Robert D. Sampson,Anastasios Georgiadis,P. V. Waldron,Yanai Duran,Arifa Naeem,Magdalena Kloc,E. Cristante,Kamil Kruczek,Katherine Warre-Cornish,Jane C. Sowden,Andrew Smith,Robin R. Ali,Robin R. Ali +18 more
TL;DR: It is shown that while integration occurs the majority of donor-reporter-labelled cells in the host arises as a result of material transfer between donor and host photoreceptors, raising the possibility of materialtransfer as a strategy for the treatment of retinal disorders.