S
S. E. Barker
Researcher at UCL Institute of Ophthalmology
Publications - 18
Citations - 1978
S. E. Barker is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Gene delivery & Retina. The author has an hindex of 15, co-authored 18 publications receiving 1787 citations. Previous affiliations of S. E. Barker include University College London & Oregon Health & Science University.
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Journal ArticleDOI
Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis
James W B Bainbridge,James W B Bainbridge,Manjit S Mehat,Venki Sundaram,Scott J Robbie,S. E. Barker,Caterina Ripamonti,Anastasios Georgiadis,Anastasios Georgiadis,Freya M. Mowat,Freya M. Mowat,Stuart G Beattie,Peter Gardner,Kecia L. Feathers,Vy Luong,Suzanne Yzer,Kamaljit S. Balaggan,Kamaljit S. Balaggan,Ananth C. Viswanathan,Thomy de Ravel,Ingele Casteels,Graham E. Holder,Nick Tyler,Fred W. Fitzke,Richard G. Weleber,Marko Nardini,Marko Nardini,Anthony T. Moore,Anthony T. Moore,Debra A. Thompson,Simon M. Petersen-Jones,Michel Michaelides,Michel Michaelides,L. Ingeborgh van den Born,Andrew Stockman,Alexander J. Smith,Gary S. Rubin,Robin R. Ali,Robin R. Ali +38 more
TL;DR: In dogs, RPE65 gene therapy with the same vector at lower doses improved vision-guided behavior, but only higher doses resulted in improvements in retinal function that were detectable with the use of ERG, and comparison with the results obtained in the dog model indicates that there is a species difference in the amount of R PE65 required to drive the visual cycle.
Journal ArticleDOI
Effective gene therapy with nonintegrating lentiviral vectors
Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Kamaljit S. Balaggan,A MacNeil,Steven J. Howe,Manfred Schmidt,Manfred Schmidt,Alexander J. Smith,Prateek K. Buch,Robert E MacLaren,Patrick N. Anderson,S. E. Barker,Yanai Duran,CC Bartholomae,CC Bartholomae,Christof von Kalle,John R. Heckenlively,Christine Kinnon,Robin R. Ali,Adrian J. Thrasher +20 more
TL;DR: The high efficiency of gene transfer and expression mediated by lentiviruses can be harnessed in vivo without a requirement for vector integration and substantially reduces the risk of insertional mutagenesis.
Journal ArticleDOI
The Drusenlike Phenotype in Aging Ccl2-Knockout Mice Is Caused by an Accelerated Accumulation of Swollen Autofluorescent Subretinal Macrophages
Ulrich F O Luhmann,Scott J Robbie,Peter M. G. Munro,S. E. Barker,Yanai Duran,Vy Luong,Fred W. Fitzke,James W B Bainbridge,Robin R. Ali,Robert E MacLaren +9 more
TL;DR: The findings suggest that the lack of Ccl2 leads to a monocyte/macrophage-trafficking defect during aging and to an impaired recruitment of these cells to sites of laser injury.
Journal ArticleDOI
Assessment of ocular transduction using single-stranded and self-complementary recombinant adeno-associated virus serotype 2/8.
M. Natkunarajah,P Trittibach,Jenny McIntosh,Yanai Duran,S. E. Barker,Alexander J. Smith,Amit C. Nathwani,Robin R. Ali +7 more
TL;DR: Improved transduction efficiency of the novel serotype AAV2/8 might facilitate the development of improved gene therapy protocols for inherited retinal degenerations, particularly those caused by defects in photoreceptor-specific genes.
Journal ArticleDOI
Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation.
Emma L. West,Rachael A. Pearson,S. E. Barker,Ulrich F O Luhmann,Robert E MacLaren,Amanda C. Barber,Yanai Duran,Alexander J. Smith,Jane C. Sowden,Robin R. Ali +9 more
TL;DR: The findings suggest that autologous donor cells are optimal for therapeutic approaches to repair the neural retina, though with immune suppression nonautologous donors may be effective.