A
A. Margot Umpleby
Researcher at University of Surrey
Publications - 68
Citations - 3279
A. Margot Umpleby is an academic researcher from University of Surrey. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 23, co-authored 66 publications receiving 2885 citations. Previous affiliations of A. Margot Umpleby include St Thomas' Hospital & King's College London.
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Journal ArticleDOI
A family with severe insulin resistance and diabetes due to a mutation in AKT2.
Stella George,Justin J. Rochford,Christian Wolfrum,Sarah L. Gray,S Schinner,Jenny C Wilson,Maria A. Soos,Peter R. Murgatroyd,Rachel M. Williams,Carlo L. Acerini,David B. Dunger,David Barford,A. Margot Umpleby,Nicholas J. Wareham,Huw Alban Davies,Alan J. Schafer,Markus Stoffel,Stephen O'Rahilly,Inês Barroso,Inês Barroso +19 more
TL;DR: A mutation in the gene encoding the protein kinase AKT2/PKBβ in a family that shows autosomal dominant inheritance of severe insulin resistance and diabetes mellitus is described, demonstrating the central importance of AKT signaling to insulin sensitivity in humans.
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Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ
David B. Savage,Garry D. Tan,Carlo L. Acerini,Susan A. Jebb,Maura Agostini,Mark Gurnell,Rachel Williams,A. Margot Umpleby,E. Louise Thomas,Jimmy D. Bell,Adrian K. Dixon,Fidelma Dunne,Romina Boiani,Saverio Cinti,Antonio Vidal-Puig,Fredrik Karpe,V. Krishna K. Chatterjee,Stephen O'Rahilly +17 more
TL;DR: The results of further detailed pathophysiological evaluation of patients with dominant-negative mutations in PPAR-gamma, the identification of affected prepubertal children within one of the original families, and the effects of thiazolidinedione therapy in two subjects are reported.
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Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT.
Roman Hovorka,Fariba Shojaee-Moradie,Paul V. Carroll,Ludovic J. Chassin,Ian J. Gowrie,Nicola Jackson,Romulus S. Tudor,A. Margot Umpleby,Richard H. Jones +8 more
TL;DR: It is concluded that, in healthy subjects during an IVGTT, the two peripheral insulin effects account jointly for approximately one-half of the overall insulin-stimulated glucose lowering, each effect contributing equally.
Journal ArticleDOI
Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome—results from a 6-month, double-blind, randomized controlled trial
Peter J. Curtis,Vera van der Velpen,Lindsey Berends,Amy Jennings,Martin Feelisch,A. Margot Umpleby,Mark L. Evans,Bernadette O. Fernandez,Mia S. Meiss,Magdalena Minnion,John F. Potter,Anne Marie Minihane,Colin D. Kay,Eric B. Rimm,Aedin Cassidy +14 more
TL;DR: Despite insulin resistance remaining unchanged, blueberries should be included in dietary strategies to reduce individual and population CVD risk, and first sustained improvements in vascular function, lipid status, and underlying NO bioactivity following 1 cup blueberries/d are shown.
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Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men
TL;DR: GH-induced increase of circulating IGF-I is augmented by T, which does not increase IGF- I in the absence of GH, but T exerted independent and additive effects on protein metabolism, F(ox) and REE.