E
E. Louise Thomas
Researcher at Imperial College London
Publications - 81
Citations - 6547
E. Louise Thomas is an academic researcher from Imperial College London. The author has contributed to research in topics: Medicine & Adipose tissue. The author has an hindex of 31, co-authored 60 publications receiving 5489 citations. Previous affiliations of E. Louise Thomas include University of Westminster & Hammersmith Hospital.
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Journal ArticleDOI
The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Gary Frost,Michelle L. Sleeth,Meliz Sahuri-Arisoylu,Blanca Lizarbe,Sebastián Cerdán,Leigh Brody,Jelena Anastasovska,Samar Ghourab,Mohammed K. Hankir,Shuai Zhang,David Carling,Jonathan R. Swann,Glenn R. Gibson,Alexander Viardot,Douglas J. Morrison,E. Louise Thomas,Jimmy D. Bell +16 more
TL;DR: It is demonstrated through 13C high-resolution magic-angle-spinning that 13C acetate from fermentation of 13C-labelled carbohydrate in the colon increases hypothalamic 13Cacetate above baseline levels, suggesting that acetate has a direct role in central appetite regulation.
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Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
Edward S. Chambers,Alexander Viardot,Arianna Psichas,Douglas J. Morrison,Kevin G Murphy,Sagen Zac-Varghese,Kenneth MacDougall,Tom Preston,Catriona Tedford,Graham Finlayson,John E. Blundell,Jimmy D. Bell,E. Louise Thomas,Shahrul Mt-Isa,Deborah Ashby,Glen R. Gibson,Sofia Kolida,Walijit S. Dhillo,Stephen R. Bloom,Wayne Morley,Stuart Clegg,Gary Frost +21 more
TL;DR: It is demonstrated for the first time that increasing colonic propionate prevents weight gain in overweight adult humans.
Journal ArticleDOI
Critical role for peptide YY in protein-mediated satiation and body-weight regulation
Rachel L. Batterham,Helen Heffron,Saloni Kapoor,Joanna E. Chivers,Keval Chandarana,Herbert Herzog,Carel W. le Roux,E. Louise Thomas,Jimmy D. Bell,Dominic J. Withers +9 more
TL;DR: It is suggested that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity.
Journal ArticleDOI
Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ
David B. Savage,Garry D. Tan,Carlo L. Acerini,Susan A. Jebb,Maura Agostini,Mark Gurnell,Rachel Williams,A. Margot Umpleby,E. Louise Thomas,Jimmy D. Bell,Adrian K. Dixon,Fidelma Dunne,Romina Boiani,Saverio Cinti,Antonio Vidal-Puig,Fredrik Karpe,V. Krishna K. Chatterjee,Stephen O'Rahilly +17 more
TL;DR: The results of further detailed pathophysiological evaluation of patients with dominant-negative mutations in PPAR-gamma, the identification of affected prepubertal children within one of the original families, and the effects of thiazolidinedione therapy in two subjects are reported.
Journal ArticleDOI
Altered adiposity after extremely preterm birth.
TL;DR: The authors' data provide evidence of causal pathways linking accelerated postnatal growth with increased total and subcutaneous adiposity, and illness severity with altered adipose tissue partitioning, and it is suggested that these observations may in part explain the associations between small size at birth and later disease.