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A. Mark Allen
Researcher at California National Primate Research Center
Publications - 5
Citations - 140
A. Mark Allen is an academic researcher from California National Primate Research Center. The author has contributed to research in topics: Antibody & Concentric hypertrophy. The author has an hindex of 3, co-authored 5 publications receiving 107 citations.
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Journal ArticleDOI
Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques.
Lark L. Coffey,Patricia A. Pesavento,Rebekah I. Keesler,Anil Singapuri,Jennifer Watanabe,Rie Watanabe,Jo Ann Yee,Eliza Bliss-Moreau,Eliza Bliss-Moreau,Christina Cruzen,Kari L. Christe,J. Rachel Reader,Wilhelm Von Morgenland,Anne M. Gibbons,A. Mark Allen,J Linnen,Kui Gao,Eric Delwart,Graham Simmons,Mars Stone,Marion C. Lanteri,Sonia Bakkour,Michael P. Busch,John H. Morrison,Koen K. A. Van Rompay +24 more
TL;DR: In 2 non-pregnant rhesus macaques inoculated with a 2015 Brazilian ZIKV strain, the animals experienced no clinical disease but developed short-lived plasma viremias that cleared as neutralizing antibody developed and viral RNA could be detected longer in whole blood than in plasma.
Journal Article
Left Ventricular Hypertrophy in Rhesus Macaques (Macaca mulatta) at the California National Primate Research Center (1992-2014).
J. Rachel Reader,Don R. Canfield,Jennifer Lane,Sreetharan Kanthaswamy,Amir Ardeshir,A. Mark Allen,Ross P. Tarara +6 more
TL;DR: Prima facie comparison of HCM and LVH suggest that further study may allow the development of spontaneously occurring LVH in rhesus macaques as a useful model of H CM, to better understand the pathogenesis of this remarkably heterogeneous disease.
Journal ArticleDOI
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques.
Koen K. A. Van Rompay,Koen K. A. Van Rompay,Katherine J. Olstad,Katherine J. Olstad,Rebecca L. Sammak,Joseph Dutra,Jennifer Watanabe,Jodie Usachenko,Ramya Immareddy,Anil Verma,Yashavanth Shaan Lakshmanappa,Brian A. Schmidt,Jamin W. Roh,Sonny R. Elizaldi,A. Mark Allen,Frauke Muecksch,Julio C. C. Lorenzi,Sarah Lockwood,Rachel E. Pollard,JoAnn L. Yee,Peter B. Nham,Amir Ardeshir,Jesse D. Deere,Jean L. Patterson,Que Dang,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz,Smita S. Iyer,Smita S. Iyer,Dennis J. Hartigan-O'Connor,Dennis J. Hartigan-O'Connor,Michel C. Nussenzweig,Michel C. Nussenzweig,J. Rachel Reader,J. Rachel Reader +35 more
TL;DR: This article investigated the therapeutic efficacy of a combination of two potent monoclonal antibodies, C135-LS and C144-LS that carry half-life extension mutations, in the rhesus macaque model of COVID-19.
Journal ArticleDOI
Respiratory Tract Explant Infection Dynamics of Influenza A Virus in California Sea Lions, Northern Elephant Seals, and Rhesus Macaques.
Hongwei Liu,Magdalena Plancarte,Erin E. Ball,Christopher M Weiss,Omar Gonzales-Viera,Karen M. Holcomb,Zhong-Min Ma,A. Mark Allen,J. Rachel Reader,Pádraig J. Duignan,Barbie Halaska,Zenab Khan,Divya Kriti,Jayeeta Dutta,Harm van Bakel,Kenneth Jackson,Patricia A. Pesavento,Walter M. Boyce,Lark L. Coffey +18 more
TL;DR: In this article, an ex vivo respiratory tract explant model was developed and used to compare infection kinetics for multiple IAV subtypes for multiple marine mammals, including sea lions, elephant seals, and rhesus macaques.
Posted ContentDOI
Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity reduces lung inflammation
Koen K. A. Van Rompay,Koen K. A. Van Rompay,Katherine J. Olstad,Katherine J. Olstad,Rebecca L. Sammak,Joseph Dutra,Jennifer Watanabe,Jodie Usachenko,Ramya Immareddy,Jamin W. Roh,Anil Verma,Yashavanth Shaan Lakshmanappa,Brian P. Schmidt,Clara Di Germanio,Nabeela Rizvi,Mars Stone,Graham Simmons,Larry J. Dumont,A. Mark Allen,Sarah Lockwood,Rachel E. Pollard,Rafael Ramiro de Assis,JoAnn L. Yee,Peter B. Nham,Amir Ardeshir,Jesse D. Deere,Jean L. Patterson,Aarti Jain,Philip L. Felgner,Smita S. Iyer,Smita S. Iyer,Michael P. Busch,J. Rachel Reader,J. Rachel Reader +33 more
TL;DR: In this article, the authors used the SARS-CoV-2 infection of rhesus macaques as a reliable animal model for testing immunotherapy strategies, and inoculated 12 adult macaques with SARS by intratracheal and intranasal routes, one day later, 8 animals were infused with pooled human CCP with a high titer of neutralizing antibodies (RVPN NT50 value of 3,003).