A
Amir Ardeshir
Researcher at California National Primate Research Center
Publications - 39
Citations - 829
Amir Ardeshir is an academic researcher from California National Primate Research Center. The author has contributed to research in topics: Medicine & Zika virus. The author has an hindex of 12, co-authored 33 publications receiving 638 citations. Previous affiliations of Amir Ardeshir include University of California, Davis.
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Journal ArticleDOI
Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.
Mara J. Broadhurst,Amir Ardeshir,Bittoo Kanwar,Julie Mirpuri,Uma Mahesh Gundra,Jacqueline M. Leung,Kirsten E. Wiens,Ivan Vujkovic-Cvijin,Charles C. Kim,Felix Yarovinsky,Nicholas W. Lerche,Joseph M. McCune,P'ng Loke +12 more
TL;DR: It is suggested that helminth treatment in primates can ameliorate colitis by restoring mucosal barrier functions and reducing overall bacterial attachment, and also by altering the communities of attached bacteria.
Journal ArticleDOI
Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems
Amir Ardeshir,Nicole R. Narayan,Nicole R. Narayan,Gema Méndez-Lagares,Gema Méndez-Lagares,Ding Lu,Ding Lu,Marcus Rauch,Yong Huang,Koen K. A. Van Rompay,Susan V. Lynch,Dennis J. Hartigan-O'Connor,Dennis J. Hartigan-O'Connor,Dennis J. Hartigan-O'Connor +13 more
TL;DR: It is shown that breast-fed and bottle-fed infant rhesus macaques develop markedly different immune systems, which remain different 6 months after weaning when the animals begin receiving identical diets.
Journal ArticleDOI
Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.
Dawn M. Dudley,Koen K. A. Van Rompay,Koen K. A. Van Rompay,Lark L. Coffey,Amir Ardeshir,Rebekah I. Keesler,Eliza Bliss-Moreau,Peta L. Grigsby,Rosemary J. Steinbach,Alec J. Hirsch,Alec J. Hirsch,Rhonda MacAllister,Heidi L. Pecoraro,Lois M. A. Colgin,Travis Hodge,Daniel N. Streblow,Daniel N. Streblow,Suzette D. Tardif,Jean L. Patterson,Manasi Tamhankar,Maxim Seferovic,Kjersti Aagaard,Claudia Sanchez San Martin,Charles Y. Chiu,Antonito T. Panganiban,Ronald S. Veazey,Xiaolei Wang,Nicholas J. Maness,Margaret H. Gilbert,Rudolf P. Bohm,Kristina M. Adams Waldorf,Michael Gale,Lakshmi Rajagopal,Lakshmi Rajagopal,Charlotte E. Hotchkiss,Emma L. Mohr,Saverio Capuano,Heather A. Simmons,Andres Mejia,Thomas C. Friedrich,Thaddeus G. Golos,David H. O’Connor +41 more
TL;DR: It is found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection.
Journal ArticleDOI
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease.
Lark L. Coffey,Rebekah I. Keesler,Patricia A. Pesavento,Kevin D. Woolard,Anil Singapuri,Jennifer Watanabe,Christina Cruzen,Kari L. Christe,Jodie Usachenko,JoAnn Yee,Victoria A. Heng,Victoria A. Heng,Eliza Bliss-Moreau,Eliza Bliss-Moreau,J. Rachel Reader,Wilhelm Von Morgenland,Anne M. Gibbons,Kenneth Jackson,Amir Ardeshir,Holly Heimsath,Sallie R. Permar,Paranthaman Senthamaraikannan,Pietro Presicce,Suhas G. Kallapur,Jeffrey M. Linnen,Kui Gao,Robert Orr,Tracy MacGill,Michelle McClure,Richard McFarland,John H. Morrison,Koen K. A. Van Rompay +31 more
TL;DR: A pregnant rhesus macaque model is established that reliably reproduces fetal neurologic defects of congenital Zika syndrome in humans, and is highly relevant to unravel determinants of fetal neuropathogenesis and to explore interventions.
Journal ArticleDOI
A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates
Jennifer R. Keeffe,Koen K. A. Van Rompay,Koen K. A. Van Rompay,Priscilla C. Olsen,Priscilla C. Olsen,Qiao Wang,Anna Gazumyan,Stephanie A. Azzopardi,Dennis Schaefer-Babajew,Yu E. Lee,Jackson B. Stuart,Anil Singapuri,Jennifer Watanabe,Jodie Usachenko,Amir Ardeshir,Mohsan Saeed,Marianna Agudelo,Thomas Eisenreich,Stylianos Bournazos,Thiago Y. Oliveira,Charles M. Rice,Lark L. Coffey,Margaret R. MacDonald,Pamela J. Bjorkman,Michel C. Nussenzweig,Michel C. Nussenzweig,Davide F. Robbiani +26 more
TL;DR: Human monoclonal antibody Z021 is reported on, a potent neutralizer that recognizes an epitope on the lateral ridge of the envelope domain III (EDIII) of ZIKV and is protective against ZikaV in mice and prevented viral escape due to mutation in macaques, a natural host for ZikV.