R
Ramya Immareddy
Researcher at California National Primate Research Center
Publications - 13
Citations - 130
Ramya Immareddy is an academic researcher from California National Primate Research Center. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 4, co-authored 8 publications receiving 51 citations. Previous affiliations of Ramya Immareddy include University of California, Davis.
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Journal ArticleDOI
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques.
Yashavanth Shaan Lakshmanappa,Sonny R. Elizaldi,Jamin W. Roh,Brian A. Schmidt,Timothy D. Carroll,Kourtney D. Weaver,Justin C Smith,Anil Verma,Jesse D. Deere,Joseph Dutra,Mars Stone,Sergej Franz,Rebecca L. Sammak,Katherine J. Olstad,J. Rachel Reader,J. Rachel Reader,Zhong-Min Ma,Nancy Nguyen,Jennifer Watanabe,Jodie Usachenko,Ramya Immareddy,Jo Ann L. Yee,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Dennis J. Hartigan-O'Connor,Dennis J. Hartigan-O'Connor,Stephen J. McSorley,John H. Morrison,John H. Morrison,Nam K. Tran,Graham Simmons,Michael P. Busch,Pamela A. Kozlowski,Koen K. A. Van Rompay,Koen K. A. Van Rompay,Christopher J. Miller,Christopher J. Miller,Smita S. Iyer,Smita S. Iyer +39 more
TL;DR: In this article, SARS-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion, resulted in transient accumulation of pro-inflammatory monocytes and proliferating Tfh cells with a Th1 profile in peripheral blood.
Journal ArticleDOI
A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques.
Koen K. A. Van Rompay,Lark L. Coffey,Tania Kapoor,Anna Gazumyan,Rebekah I. Keesler,Andrea Jurado,Avery Peace,Marianna Agudelo,Jennifer Watanabe,Jodie Usachenko,Anil Singapuri,Ramya Immareddy,Amir Ardeshir,Jackson B. Stuart,Stylianos Bournazos,Jeffrey V. Ravetch,Paul J. Balderes,Ivo C. Lorenz,Shannon R. Esswein,Jennifer R. Keeffe,Pamela J. Bjorkman,Qiao Wang,Qiao Wang,Charles M. Rice,Margaret R. MacDonald,Michel C. Nussenzweig,Michel C. Nussenzweig,Davide F. Robbiani +27 more
TL;DR: It is shown that prophylactic administration of two engineered antibodies to pregnant macaques partially protects against fetal neurologic damage and limits vertical transmission of ZIKV, and maternal passive immunization with two antibodies to EDIII can shield primate fetuses from the harmful effects of ZikV.
Journal ArticleDOI
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques.
Koen K. A. Van Rompay,Koen K. A. Van Rompay,Katherine J. Olstad,Katherine J. Olstad,Rebecca L. Sammak,Joseph Dutra,Jennifer Watanabe,Jodie Usachenko,Ramya Immareddy,Anil Verma,Yashavanth Shaan Lakshmanappa,Brian A. Schmidt,Jamin W. Roh,Sonny R. Elizaldi,A. Mark Allen,Frauke Muecksch,Julio C. C. Lorenzi,Sarah Lockwood,Rachel E. Pollard,JoAnn L. Yee,Peter B. Nham,Amir Ardeshir,Jesse D. Deere,Jean L. Patterson,Que Dang,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz,Smita S. Iyer,Smita S. Iyer,Dennis J. Hartigan-O'Connor,Dennis J. Hartigan-O'Connor,Michel C. Nussenzweig,Michel C. Nussenzweig,J. Rachel Reader,J. Rachel Reader +35 more
TL;DR: This article investigated the therapeutic efficacy of a combination of two potent monoclonal antibodies, C135-LS and C144-LS that carry half-life extension mutations, in the rhesus macaque model of COVID-19.
Posted ContentDOI
SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques
Sonny R. Elizaldi,Yashavanth Shaan Lakshmanappa,Jamin W. Roh,Brian A. Schmidt,Timothy D. Carroll,Kourtney D. Weaver,Justin C Smith,Jesse D. Deere,Joseph Dutra,Mars Stone,Rebecca L. Sammak,Katherine J. Olstad,J. Rachel Reader,Zhong-Min Ma,Nancy Nguyen,Jennifer Watanabe,Jodie Usachaenko,Ramya Immareddy,JoAnn L. Yee,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Dennis J. Hartigan-O'Connor,Stephen J. McSorley,John H. Morrison,Nam K Tran,Graham Simmons,Michael P. Busch,Pamela A. Kozlowski,Koen K. A. Van Rompay,Christopher J. Miller,Smita S. Iyer +31 more
TL;DR: It is reported that, following infection with SARS-CoV-2, adult rhesus macaques exhibited transient accumulation of activated, proliferating Tfh cells in their peripheral blood on a transitory basis and the data suggest that a vaccine promoting Th1-type T fh responses that target the S protein may lead to protective immunity.
Posted ContentDOI
A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques
Koen K. A. Van Rompay,Koen K. A. Van Rompay,Lark L. Coffey,Tania Kapoor,Anna Gazumyan,Rebekah I. Keesler,Andrea Jurado,Avery Peace,Marianna Agudelo,Jennifer Watanabe,Jodie Usachenko,Anil Singapuri,Ramya Immareddy,Amir Ardeshir,Jackson B. Stuart,Stylianos Bournazos,Jeffrey V. Ravetch,Paul J. Balderes,Ivo C. Lorenz,Shannon R. Esswein,Jennifer R. Keeffe,Pamela J. Bjorkman,Qiao Wang,Qiao Wang,Charles M. Rice,Margaret R. MacDonald,Michel C. Nussenzweig,Michel C. Nussenzweig,Davide F. Robbiani +28 more
TL;DR: It is shown that prophylactic administration of two engineered antibodies, Z004 and Z021, to pregnant macaques partially protects against fetal neurologic damage and limits vertical transmission of ZIKV.