A. Wehnert

TL;DR: The data indicate that the APP gene is tightly linked to HCHWA-D and therefore, in contrast to familial Alzheimer's disease, cannot be excluded as the site of mutation in HCH WA-D.

TL;DR: A significant association between APOE*4 and EOAD is demonstrated which is modified by family history of dementia, but an increase in EOAD risk for APoe*4 heterozygotes could only be shown in subjects with a positive family history.

TL;DR: A systematic mutation analysis of all coding and 5'-non-coding exons of PS -1 and PS -2 in a population-based epidemiological series of 101 unrelated familial and sporadic presenile AD cases found polymorphisms were detected in the promoter and the 5'- non-Coding region of PS-1 and in intronic and exonic sequences of PS -- that will be useful in genetic association studies.

TL;DR: It is demonstrated that the gene for plaque core A4-amyloid cannot be the locus of a defect causing Alzheimer's disease in these families, and alterations in the plaque core amyloid gene cannot explain the molecular pathology for all cases of Alzheimer's Disease.

TL;DR: The observation of two mutations in functionally different domains suggest that onset age and severity of AD may not be very helpful predictors of the location of putative S182 mutations.