G. De Winter

TL;DR: The inheritance of five polymorphic DNA markers from the proximal long arm of chromosome 21 in a large unselected series of pedi-grees with familial Alzheimer's disease suggests that Alzheimer's Disease is not a single entity, but rather results from genetic defects on chromosome 21 and from other genetic or nongenetic factors.

TL;DR: This work examined two extended histopathologically confirmed EOAD pedigrees, AD/A and AD/B, with highly informative short tandem repeat (STR) polymorphisms and found complete linkage of the disease to a (CA)n dinucleotide repeat polymorphism at locus D14S43 in 14q24.3.

TL;DR: The observation of two mutations in functionally different domains suggest that onset age and severity of AD may not be very helpful predictors of the location of putative S182 mutations.

TL;DR: Clinical and neuropathologic data is reported on 2 large Belgian families with FAD in which 17 autopsies of the CNS were obtained, and the amyloid deposits for the A4 protein were immunostained, and they were negative for prion-associated protein immunoreactivity.

TL;DR: This work extensively analyzed a multi-generation Charcot-Marie-Tooth family by using molecular genetic techniques in order to localize the CMT gene defect and found that the mutation is most likely located on the chromosome 17p arm, distal of D17S71.