J
June L. Round
Researcher at University of Utah
Publications - 98
Citations - 15433
June L. Round is an academic researcher from University of Utah. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 33, co-authored 82 publications receiving 12843 citations. Previous affiliations of June L. Round include Huntsman Cancer Institute & University of California, Los Angeles.
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Journal ArticleDOI
The gut microbiota shapes intestinal immune responses during health and disease
TL;DR: Findings indicating that developmental aspects of the adaptive immune system are influenced by bacterial colonization of the gut are discussed, and the possibility that the mammalian immune system, which seems to be designed to control microorganisms, is in fact controlled by microorganisms is raised.
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A microbial symbiosis factor prevents intestinal inflammatory disease
TL;DR: It is reported here that the prominent human symbiont Bacteroides fragilis protects animals from experimental colitis induced by Helicobacter hepaticus and that molecules of the bacterial microbiota can mediate the critical balance between health and disease.
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Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
TL;DR: It is demonstrated that PSA is not only able to prevent, but also cure experimental colitis in animals, and co-opts the Treg lineage differentiation pathway in the gut to actively induce mucosal tolerance.
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The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota
June L. Round,S. Melanie Lee,Jennifer S. Li,Gloria Tran,Bana Jabri,Talal A. Chatila,Sarkis K. Mazmanian +6 more
TL;DR: It is proposed that the immune system can discriminate between pathogens and the microbiota through recognition of symbiotic bacterial molecules in a process that engenders commensal colonization.
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MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development
Ryan M. O'Connell,Daniel Kahn,Daniel Kahn,William S. Gibson,June L. Round,Rebecca L. Scholz,Aadel A. Chaudhuri,Melissa Kahn,Dinesh S. Rao,Dinesh S. Rao,David Baltimore +10 more
TL;DR: It is shown that one aspect of miR-155 function is the promotion of T cell-dependent tissue inflammation, suggesting that miR -155 might be a promising therapeutic target for the treatment of autoimmune disorders.