There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

J. Appl. Cryst.の発刊に際して

비만아 부모의 돌봄 경험: q 방법론

Interplay between conformation and crystal packing in aryl propargyl ethers: Structural and spectroscopic properties of 2-(prop-2-yn-1-yloxy)acene derivatives

A Comparative Study of Synthetic Approaches Towards Total Synthesis of Mandelalide A, An Anti-Lung Cancer Metabolite From Lissoclinum Ascidian

In the title mol­ecule, C13H15Cl2NO, the cyclohexane ring adopts a chair conformation. The aromatic ring plane is oriented with respect to the N/O/C plane at a dihedral angle of 51.88 (7)°. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into infinite chains along the [010] direction.

/pdf/2-4-dichloro-n-cyclo-hexyl-benzamide-1w7e32ws7v.pdf

2,4-Dichloro-N-cyclo-hexyl-benzamide.

A series of N-(3-(substituted-alkylor halophenyl)-4-methylthiazol-2(3H)-ylidene)-substituted alkylor halo-benzamides 21 – 40 were prepared by base-catalyzed cyclization of the corresponding 1-(substituted-alkylor halo-benzoyl)-3-(substituted-halophenyl)thioureas 1 – 20. Substituted pyrazolo[4,3-d]thiazol-5(6aH)-ylidene)benzamides 45a –d were synthesized by cycloaddition of compound 45 with the reactive cumulene intermediates 42a –d. All compounds were evaluated for their antiviral activity against the replication of HIV-1 and HIV-2 in MT-4. Compounds 35 and 39 showed an IC50 of 2.02 μgmL−1 and 0.40 μgmL−1 against the HIV-2 strain ROD with CC50 of ≥ 104.00 μgmL−1 and > 125.00 μgmL−1, respectively, resulting in a selectivity index of ≥ 52 and > 313. Based on the chemical structure of compounds 35 and 39, these molecules can be proposed to act as NNRTIs. However, it is exceptional to observe an antiretroviral activity that is limited to HIV-2.

New Substituted Thiazol‐2‐ylidene‐benzamides and Their Reaction with 1‐Aza‐2‐azoniaallene Salts. Synthesis and anti‐HIV Activity.

(E)-2-(3-Hydroxy-4-methoxybenzylidene)hydrazinecarbothioamide 3 was synthesized by reacting thiosemicarbazide with 2-hydorxy-3-methoxybenzaldehyde in dry ethanol. The structure was elucidated by spectroscopic (FT-IR, 1H NMR, and 13C NMR) and single crystal X-ray diffraction techniques. A detailed analysis of the intermolecular interactions has been performed based on the Hirshfeld surfaces and their associated two-dimensional fingerprint plots. DFT, spectroscopic, and electrochemical DNA-binding analysis confirmed that the compound is reactive to bind with DNA. Viscometric studies suggested that compound 3 has a mixed mode of interaction and intercalated into the DNA base pairs predominantly along with the possibility of electrostatic interactions. Graphical Abstract.

Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DFT, and DNA-Binding Studies of (E)-2-(3-Hydroxy-4-Methoxybenzylidene)Hydrazinecarbothioamide

Aamer Saeed

Papers

Interplay between conformation and crystal packing in aryl propargyl ethers: Structural and spectroscopic properties of 2-(prop-2-yn-1-yloxy)acene derivatives

A Comparative Study of Synthetic Approaches Towards Total Synthesis of Mandelalide A, An Anti-Lung Cancer Metabolite From Lissoclinum Ascidian

2,4-Dichloro-N-cyclo-hexyl-benzamide.

New Substituted Thiazol‐2‐ylidene‐benzamides and Their Reaction with 1‐Aza‐2‐azoniaallene Salts. Synthesis and anti‐HIV Activity.

Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DFT, and DNA-Binding Studies of (E)-2-(3-Hydroxy-4-Methoxybenzylidene)Hydrazinecarbothioamide