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Aamer Saeed
Researcher at Quaid-i-Azam University
Publications - 628
Citations - 8999
Aamer Saeed is an academic researcher from Quaid-i-Azam University. The author has contributed to research in topics: Crystal structure & Chemistry. The author has an hindex of 33, co-authored 570 publications receiving 6148 citations. Previous affiliations of Aamer Saeed include Leibniz University of Hanover & King's College London.
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Design, synthesis and biological evaluation of Trinary Benzocoumarin-Thiazoles-Azomethines derivatives as Effective and Selective Inhibitors of Alkaline Phosphatase
Pervaiz Ali Channar,Hina Irum,Abid Mahmood,Ghulam Shabir,Sumera Zaib,Aamer Saeed,Zaman Ashraf,Fayaz Ali Larik,Joanna Lecka,Jean Sévigny,Jamshed Iqbal +10 more
TL;DR: The new trinary Benzocoumarin-Thiazoles-Azomethine derivatives having three bioactive scaffolds in a single structural unit exhibited the potent inhibition profile on both isozymes of alkaline phosphatase i.e., h-TNAP and h-IAP.
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4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5′-nucleotidase with potential anticancer activity
Sidra Hassan,Syeda Abida Ejaz,Aamer Saeed,Muddasar Shehzad,Shafiullah Khan,Joanna Lecka,Jean Sévigny,Ghulam Shabir,Jamshed Iqbal +8 more
TL;DR: To design potent and selective inhibitors, new derivatives of 4-aminopyridine have been synthesized (10a-10m) and their structures were established on the basis of spectral data and the effect of nature and position of substituent was interestingly observed and justified on the based of their detailed structure activity relationships against both families of ecto-nucleotidase.
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Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives
Fayaz Ali Larik,Aamer Saeed,Danish Shahzad,Muhammad Faisal,Hesham R. El-Seedi,Haroon Mehfooz,Pervaiz Ali Channar +6 more
TL;DR: This review aims to provide comprehensive insight for the synthetic endeavors devoted towards the synthesis of a versatile drug spironolactone and its analogues/derivatives to help the synthetic chemist to design and prepare new more effective derivatives.
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Assessing the effectiveness of oxidative approaches for the synthesis of aldehydes and ketones from oxidation of iodomethyl group
TL;DR: In this paper, aldehydes and ketones were constructed from the oxidation of halomethyl groups in benzylic iodides and allylic iodide using numerous well-known approaches reported in the literature.
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Intermolecular interactions in antipyrine-like derivatives 2-halo-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamides: X-ray structure, Hirshfeld surface analysis and DFT calculations
Aamer Saeed,Asma Khurshid,Ulrich Flörke,Gustavo A. Echeverría,Oscar E. Piro,Diego M. Gil,Mariana Rocha,Antonio Frontera,Hesham R. El-Seedi,Amara Mumtaz,Mauricio F. Erben +10 more
TL;DR: The synthesis, X-ray structure characterization, Hirshfeld surface analysis and DFT calculations of two new antipyrine derivatives are reported in this paper, which are isostructural and crystallize in the monoclinic P21/c space group.