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Aarathi Minisandram
Researcher at California Institute of Technology
Publications - 4
Citations - 222
Aarathi Minisandram is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Progenitor cell & Leukemia. The author has an hindex of 3, co-authored 4 publications receiving 198 citations.
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Journal ArticleDOI
Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A
Aadel A. Chaudhuri,Alex Yick Lun So,Arnav Mehta,Aarathi Minisandram,Nikita Sinha,Vanessa D. Jonsson,Dinesh S. Rao,Ryan M. O'Connell,David Baltimore +8 more
TL;DR: Investigating the mechanism by which miR-125b regulates hematopoiesis, it was found that, among a panel of candidate targets, the mRNA for Lin28A, an induced pluripotent stem cell gene, was most repressed by miR -125b in mouse hematoietic stem and progenitor cells.
Journal ArticleDOI
Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias.
Alex Yick Lun So,Reeshelle Sookram,Aadel A. Chaudhuri,Aadel A. Chaudhuri,Aarathi Minisandram,David Cheng,Catherine B. Xie,Ee Lyn Lim,Yvette Garcia Flores,Shuai Jiang,Jocelyn T. Kim,Christopher L. Keown,Parameswaran Ramakrishnan,David Baltimore +13 more
TL;DR: It is demonstrated that miR-125b induces myeloid leukemia by enhancing myeloids progenitor output from stem cells as well as inducing immortality, self-renewal, and tumorigenesis in myeloidal progenitors.
Journal ArticleDOI
Regulation of APC development, immune response, and autoimmunity by Bach1/HO-1 pathway in mice
Alex Yick Lun So,Yvette Garcia-Flores,Aarathi Minisandram,Ayana Martin,Konstantin Taganov,Mark Boldin,David Baltimore +6 more
TL;DR: It is shown that the Cap'n'collar member Bach1 regulates the generation of APCs, specifically macrophages and dendritic cells, in mice, and an increase in hematopoietic stem-progenitor cells in these mice is observed, suggesting a developmental block in the progression of HSPCs to CMP-Flk2(+) and subsequently APCs.