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Catherine B. Xie
Researcher at Yale University
Publications - 15
Citations - 520
Catherine B. Xie is an academic researcher from Yale University. The author has contributed to research in topics: CD8 & Cytotoxic T cell. The author has an hindex of 9, co-authored 15 publications receiving 281 citations. Previous affiliations of Catherine B. Xie include California Institute of Technology & University of Cambridge.
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Journal ArticleDOI
Three Dimensional Bioprinting of a Vascularized and Perfusable Skin Graft Using Human Keratinocytes, Fibroblasts, Pericytes, and Endothelial Cells
Tânia Baltazar,Jonathan Merola,Carolina Motter Catarino,Catherine B. Xie,Nancy C. Kirkiles-Smith,Vivian K. Lee,Stéphanie Yuki Kolbeck Hotta,Guohao Dai,Xiaowei Xu,Frederico Castelo Ferreira,W. Mark Saltzman,Jordan S. Pober,Pankaj Karande +12 more
TL;DR: Three Dimensional printing can be used to generate multilayered vascularized human skin grafts that can potentially overcome the limitations of graft survival observed in current avascular skin substitutes.
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Complement Membrane Attack Complex: New Roles, Mechanisms of Action, and Therapeutic Targets.
TL;DR: New discoveries into the structure and biophysical properties of MAC revealed heterogenous MAC precursors and conformations that provide insights into MAC function and provide an updated framework to therapeutic approaches that can target MAC assembly, signaling, and proinflammatory effects in various complement-mediated diseases.
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Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods
TL;DR: Building on the previous efforts to generate thermostable chimeric fungal cellobiohydrolase I (CBH I) cellulases by structure-guided recombination, FoldX and a 'consensus' sequence approach were used to identify individual mutations present in the five homologous parent CBH I enzymes which further stabilize the chimeras.
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Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ-Primed Human Endothelium.
Catherine B. Xie,Lingfeng Qin,Guangxin Li,Caodi Fang,Nancy C. Kirkiles-Smith,George Tellides,Jordan S. Pober,Dan Jane-wit +7 more
TL;DR: In response to antibody-mediated complement activation, IFN-γ-primed human ECs internalize MAC, triggering both endosomal-associated NIK-dependent NLRP3 inflammasome assembly and IL-1 synthesis, resulting in autocrine/paracrine IL- 1β-mediated increases in EC immunogenicity.
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Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias.
Alex Yick Lun So,Reeshelle Sookram,Aadel A. Chaudhuri,Aadel A. Chaudhuri,Aarathi Minisandram,David Cheng,Catherine B. Xie,Ee Lyn Lim,Yvette Garcia Flores,Shuai Jiang,Jocelyn T. Kim,Christopher L. Keown,Parameswaran Ramakrishnan,David Baltimore +13 more
TL;DR: It is demonstrated that miR-125b induces myeloid leukemia by enhancing myeloids progenitor output from stem cells as well as inducing immortality, self-renewal, and tumorigenesis in myeloidal progenitors.