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Aaron F. Straight
Researcher at Stanford University
Publications - 98
Citations - 12950
Aaron F. Straight is an academic researcher from Stanford University. The author has contributed to research in topics: Centromere & Kinetochore. The author has an hindex of 44, co-authored 92 publications receiving 12054 citations. Previous affiliations of Aaron F. Straight include University of Illinois at Urbana–Champaign & University of California, San Francisco.
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Journal ArticleDOI
Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor
Aaron F. Straight,Amy Cheung,John Limouze,Irene A. Chen,Nicholas J. Westwood,James R. Sellers,Timothy J. Mitchison +6 more
TL;DR: It is shown that exit from the cytokinetic phase of the cell cycle depends on ubiquitin-mediated proteolysis and continuous signals from microtubules are required to maintain the position of the cleavage furrow, and these signals control the localization of myosin II independently of other furrow components.
Journal ArticleDOI
In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition.
Carmen C. Robinett,Aaron F. Straight,Gang Li,Carol Willhelm,Gail Sudlow,Andrew W. Murray,Andrew S. Belmont +6 more
TL;DR: A new method for in situ localization of DNA sequences that allows excellent preservation of nuclear and chromosomal ultrastructure and direct, in vivo observations is reported.
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Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.
Jingsong Xu,Fei Wang,Alexandra Van Keymeulen,Alexandra Van Keymeulen,Paul Herzmark,Aaron F. Straight,Kathleen Kelly,Yoh Takuwa,Naotoshi Sugimoto,Timothy J. Mitchison,Henry R. Bourne +10 more
TL;DR: Like neutrophilic leukocytes, differentiated HL-60 cells respond to chemoattractant by adopting a polarized morphology, with F-actin in a protruding pseudopod at the leading edge and contractile actin-myosin complexes at the back and sides.
Journal ArticleDOI
Interphase chromosomes undergo constrained diffusional motion in living cells.
Wallace F. Marshall,Aaron F. Straight,John F. Marko,Jason R. Swedlow,Abby F. Dernburg,Andrew S. Belmont,Andrew W. Murray,David A. Agard,John W. Sedat +8 more
TL;DR: It is found that chromatin is free to undergo substantial Brownian motion, but that a given chromatin segment is confined to a subregion of the nucleus, which leads to a model for the regulation of chromosome interactions by nuclear architecture.
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GFP tagging of budding yeast chromosomes reveals that protein–protein interactions can mediate sister chromatid cohesion
TL;DR: It is concluded that sister Chromatid separation in budding yeast can occur in the absence of microtubule-dependent forces, and that protein complexes that can bind two different DNA molecules are capable of holding sister chromatids together.