Abdeslam Mouihate

TL;DR: These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors.

TL;DR: This article showed that a single LPS injection during a critical postnatal period causes a longlasting increase in seizure susceptibility that is strongly dependent on tumor necrosis factor α (TNFα) antibody and mimicked by intracerebroventricular injection of rat recombinant TNFα.

TL;DR: Rats treated with LPS showed significantly greater adult seizure susceptibility to all convulsants, as well as increased cytokine release and enhanced neuronal degeneration within the hippocampus after limbic seizures, indicating that a single LPS injection during a critical postnatal period causes a long-lasting increase in seizure susceptibility that is strongly dependent on TNFα.

TL;DR: In this article, the authors showed that early life immune exposure will alter febrile and neurochemical responses to immune stress in adulthood, and that the characteristic reduction in activity that accompanies fever was unaltered as a function of neonatal LPS exposure.

TL;DR: A single bout of inflammation during development can programme specific and persistent differences in NR mRNA subunit expression in the hippocampus, which could be associated with behavioural and cognitive deficits in adulthood.