Q
Quentin J. Pittman
Researcher at University of Calgary
Publications - 328
Citations - 16485
Quentin J. Pittman is an academic researcher from University of Calgary. The author has contributed to research in topics: Vasopressin & Excitatory postsynaptic potential. The author has an hindex of 63, co-authored 324 publications receiving 15404 citations. Previous affiliations of Quentin J. Pittman include Centre for Mental Health & Alberta Children's Hospital.
Papers
More filters
Journal ArticleDOI
Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors
Marja D. Van Sickle,Marnie Duncan,Philip J. Kingsley,Abdeslam Mouihate,Paolo Urbani,Ken Mackie,Nephi Stella,Alexandros Makriyannis,Daniele Piomelli,Joseph S. Davison,Lawrence J. Marnett,Vincenzo Di Marzo,Quentin J. Pittman,Kamala D. Patel,Keith A. Sharkey +14 more
TL;DR: These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors.
Journal ArticleDOI
Epilepsy and brain inflammation.
TL;DR: The clinical observations in drug-resistant human epilepsies and the experimental findings in adult and immature rodents linking brain inflammation to the epileptic process in a causal and reciprocal manner are reported.
Journal ArticleDOI
Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation
Kiarash Riazi,Michael A. Galic,J. Brent Kuzmiski,Winnie Ho,Keith A. Sharkey,Quentin J. Pittman +5 more
TL;DR: The finding of a microglia-dependent TNFα-mediated increase in CNS excitability provides insight into potential mechanisms underlying the disparate neurological and behavioral changes associated with chronic inflammation.
Journal ArticleDOI
Cytokines and brain excitability.
TL;DR: Findings from both the clinical literature and from in vivo and in vitro laboratory studies suggest that cytokines can increase seizure susceptibility and may be involved in epileptogenesis.
Journal ArticleDOI
Postnatal Inflammation Increases Seizure Susceptibility in Adult Rats
Michael A. Galic,Kiarash Riazi,James G. Heida,Abdeslam Mouihate,Neil M. Fournier,Sarah J. Spencer,Lisa E. Kalynchuk,G. Campbell Teskey,Quentin J. Pittman +8 more
TL;DR: This article showed that a single LPS injection during a critical postnatal period causes a longlasting increase in seizure susceptibility that is strongly dependent on tumor necrosis factor α (TNFα) antibody and mimicked by intracerebroventricular injection of rat recombinant TNFα.