Abdo A. Elfiky

TL;DR: The results suggest the effectiveness of Ribavirin, Remdesivir, Sofosbuvir, Galides Vivir, and Tenofovir as potent drugs against SARS-CoV-2 since they tightly bind to its RdRp.

TL;DR: The results suggest the effectiveness of Sofosbuvir, IDX-184, Ribavirin, and Remidisvir as potent drugs against the newly emerged HCoV disease.

TL;DR: The COVID-19 spike binding site to the cell-surface receptor (Glucose Regulated Protein 78 (GRP78) is predicted using combined molecular modeling docking and structural bioinformatics and sequence and structural alignments show that four regions have sequence and physicochemical similarities to the cyclic Pep42.

TL;DR: The present review summarizes structure, function, and different mechanisms GRP78 mediate in response to normal or stress conditions aiming to prevent the virulence of pathogens and cancer.

TL;DR: Molecular modeling, docking, and dynamics simulations are used to build a model for the viral protein RNA-dependent RNA polymerase (RdRp) and test its binding affinity to some clinically approved drugs and drug candidates and show the effectiveness of Sofosbuvir, Ribavirin, Galidesivir, RemdesivIR, Favipiravir, and Hydroxychloroquine in binding to SARS-CoV-2 RdRp.