Showing papers in "Journal of Infection in 2020"

TL;DR: This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.

TL;DR: Clinical manifestations such as fever, shortness of breath or dyspnea were associated with the progression of disease, and laboratory examination such as aspartate amino transferase(AST) > 40U/L, creatinine(Cr) ≥ 133mol/l, hypersensitive cardiac troponin I(hs-cTnI) > 28pg/mL, procalcitonin(PCT) > 0.5mg/L predicted the deterioration of disease.

TL;DR: A retrospective study of patients with new coronavirus pneumonia who were hospitalized in Hainan Provincial People's Hospital from January 15, 2020 to February 18, 2020, finds that elderly patients with COVID-19 are more likely to progress to severe disease.

TL;DR: A low proportion of COVID-19 patients have a bacterial co-infection; less than in previous influenza pandemics; and these findings do not support the routine use of antibiotics in the management of confirmed CO VID-19 infection.

TL;DR: The measures to prevent transmission was very successful at early stage, the next steps on the COVID-19 infection should be focused on early isolation of patients and quarantine for close contacts in families and communities in Beijing.

TL;DR: High proportion of severe to critical cases and high fatality rate were observed in the elderly COVID-19 patients and close monitoring and timely treatment should be performed for the elderly patients at high risk.

TL;DR: The majority of COVID-19 cases are symptomatic with a moderate CFR, and patients living in Wuhan, older patients, and those with medical comorbidities tend to have more severe clinical symptoms and higher CFR.

TL;DR: Most patients presented with a mild infection in this retrospective cohort study, but the imaging pattern of multifocal peripheral ground glass or mixed opacity with predominance in the lower lung is highly suspicious of COVID-19 in the first week of disease onset.

TL;DR: Most patients requiring hospitalization for COVID-19 still have persistent symptoms, and there were few differences between HRQoL between ward and ICU patients, although these findings must be confirmed in larger cohorts, including more severe patients.

TL;DR: NLR is an independent risk factor of the in-hospital mortality for COVID-19 patients especially for male, and assessment of NLR may help identify high risk individuals with CO VID-19.

TL;DR: The clinical progression pattern suggests that early control of viral replication and application of host-directed therapy in later stage is essential to improve the prognosis of CVOID-19.

TL;DR: Community-wide mask wearing may contribute to the control of CO VID-19 by reducing virus shedding in saliva and respiratory droplets from individuals with subclinical or mild COVID-19.

TL;DR: There is a relatively consistent trajectory of SARS-CoV-2 viral load over the course of COVID-19 from respiratory tract samples, however the duration of infectivity remains uncertain.

TL;DR: The role of saliva in COVID-19 diagnosis could not be limited to a qualitative detection of the virus, but it may also provide information about the clinical evolution of the disease.

TL;DR: The occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm are reviewed in attempt to provide valuable medication guidance for clinical treatment.

TL;DR: CT imaging presentations of NCP are mostly patchy ground glass opacities in the peripheral areas under the pleura with partial consolidation which will be absorbed with formation of fibrotic stripes if improved.

TL;DR: In patients with COVID-19, the apparent favorable clinical response with arbidol and LPV/r supports further LPV /r only treatment, and both initiated after diagnosis.

TL;DR: The COVID-19 spike binding site to the cell-surface receptor (Glucose Regulated Protein 78 (GRP78) is predicted using combined molecular modeling docking and structural bioinformatics and sequence and structural alignments show that four regions have sequence and physicochemical similarities to the cyclic Pep42.

TL;DR: This article has been withdrawn at the request of the author(s) and/or editor and the Publisher apologizes for any inconvenience this may cause.

TL;DR: The pulmonary involvement in children with COVID-19 was mild with a focal GGO or consolidation, and the clinically-diagnosed cases were vulnerable to more pulmonary involvement.

TL;DR: Graphical abstract Image, graphical abstract images showing how the model transformed from a discrete-time model to a 3D model with real-time consequences has changed over time.

TL;DR: The data indicate that arbidol monotherapy may be superior to lopinavir/ritonavir in treating COVID-19, and no apparent side effects were found in both groups.

TL;DR: SARS-CoV-2-infection presented strong infectivity during the incubation-period with rapid transmission in this cluster of youngsters outside Wuhan, China, and COVID-19 developed in these youngsters had fast onset and various nonspecific atypical manifestations, and were much milder than in older patients as previously reported.

TL;DR: Findings from this small group of cases suggested that there was currently evidence for reactivation of SARS-CoV-2 and there might be no specific clinical characteristics to distinguish them.

TL;DR: Patients with severe conditions are more likely to require corticosteroids therapy and use is associated with increased mortality in patients with coronavirus pneumonia, according to this meta-analysis.

TL;DR: Serological ICG strip assay in detecting SARS-CoV-2 infection is both sensitive and consistent, which is considered as an excellent supplementary approach in clinical application.

TL;DR: Viral detection from throat gargling sample could be an alternative diagnostic method for mild COVID-19 patients with scarce sputum andSputum remained the most sensitive specimen for viral detection after clinical symptoms resolved.

TL;DR: A national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virological-confirmed acute CO VID-19 episode is reported, and either re-infection or reactivation hypothesis is discussed.

TL;DR: Wang et al. as discussed by the authors characterized the CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia and found that the predominant feature of CT findings in this cohort was ground glass opacity (GGO) with peripheral (44, 75.9%) distribution, unilateral location (34, 58.6%), often accompanied by characteristic signs.