A
Abhay Kulkarni
Publications - 21
Citations - 179
Abhay Kulkarni is an academic researcher. The author has contributed to research in topics: Antagonist & Receptor. The author has an hindex of 6, co-authored 19 publications receiving 148 citations.
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Journal ArticleDOI
Transient Receptor Potential Ankyrin 1 Receptor Activation In Vitro and In Vivo by Pro-tussive Agents: GRC 17536 as a Promising Anti-Tussive Therapeutic
Indranil Mukhopadhyay,Abhay Kulkarni,Sarika Aranake,Pallavi V. Karnik,Mahesh Shivarama Shetty,Sandeep Thorat,Indraneel Ghosh,Dinesh Pradeep Wale,Vikram Mansingh Bhosale,Neelima Khairatkar-Joshi +9 more
TL;DR: The potential utility of TRPA1 antagonist such as GRC 17536 in the treatment of miscellaneous chronic cough conditions arising due to diverse causes but commonly driven viaTRPA1 is highlighted.
Journal ArticleDOI
Blocking TRPA1 in Respiratory Disorders: Does It Hold a Promise?
TL;DR: In vitro, animal and human evidences that strengthen the proposed role of TRPA1 in modulation of specific airway sensory responses are focused on and preclinical and clinical progress of selected TRpa1 antagonists are also focused on.
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Design and synthesis of novel xanthine derivatives as potent and selective A 2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases.
Sujay Basu,Dinesh A. Barawkar,Vidya Ramdas,Meena Patel,Yogesh Waman,Anil Panmand,Santosh Kumar,Sachin Thorat,Minakshi Naykodi,Arnab Goswami,B. Srinivasa Reddy,Vandna Prasad,Sandhya Chaturvedi,Azfar Quraishi,Suraj Menon,Shalini Paliwal,Abhay Kulkarni,Vikas Karande,Indraneel Ghosh,Syed Mustafa,Siddhartha De,Vaibhav Jain,Ena Ray Banerjee,Sreekanth R. Rouduri,Venkata P. Palle,Anita Chugh,Kasim A. Mookhtiar +26 more
TL;DR: Several prop-2-ynylated C8-aryl or heteroaryl substitutions on xanthine chemotype were explored and found that 1-prop-2 -ynyl-1H-pyrazol-4-yl moiety was better tolerated at the C8 position and provided better selectivity for A2BAdoR compared to that of para-substituted analogs.
Journal ArticleDOI
A2B adenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives.
Sujay Basu,Dinesh A. Barawkar,Vidya Ramdas,Yogesh Waman,Meena Patel,Anil Panmand,Santosh Kumar,Sachin Thorat,Rajesh Bonagiri,Dilip Jadhav,Partha P. Mukhopadhyay,Vandna Prasad,B. Srinivasa Reddy,Arnab Goswami,Sandhya Chaturvedi,Suraj Menon,Azfar Quraishi,Indraneel Ghosh,Sushant Dusange,Shalini Paliwal,Abhay Kulkarni,Vikas Karande,Rhishikesh Thakre,Gaurav Bedse,Sreekanth R. Rouduri,Jayasagar Gundu,Venkata P. Palle,Anita Chugh,Kasim A. Mookhtiar +28 more
TL;DR: SAR optimization resulted in identification of two novel A2BAdoR antagonists, 8-{1-[5-Oxo-1-(4-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-xanthine (31) and 8-1-{2- Oxo-2-[4-(3- Trif
Journal ArticleDOI
Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor.
Nagarajan Muthukaman,Sanjay Deshmukh,Neelam Sarode,Shital Tondlekar,Macchindra Tambe,Dnyandeo Pisal,Mahamadhanif S. Shaikh,Vidya Ganapati Kattige,Srinivasa Honnegowda,Vikas Karande,Abhay Kulkarni,Satyawan Jadhav,Mahamad Yunnus A. Mahat,Girish S. Gudi,Neelima Khairatkar-Joshi,Laxmikant Atmaram Gharat +15 more
TL;DR: Lead 17d displayed excellent in vitro selectivity over mPGES-2, cPGES, COX-enzymes (COX-1, 2), selectivity against other prostanoid synthases, favorable hERG and CEREP panel profile, and good oral pharmacokinetic profiles and good CNS B/P ratio in rat and guinea pig.