M
Meena Patel
Publications - 13
Citations - 159
Meena Patel is an academic researcher. The author has contributed to research in topics: Adenosine receptor & Adenosine A2A receptor. The author has an hindex of 8, co-authored 12 publications receiving 133 citations.
Papers
More filters
Journal ArticleDOI
Design and synthesis of novel xanthine derivatives as potent and selective A 2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases.
Sujay Basu,Dinesh A. Barawkar,Vidya Ramdas,Meena Patel,Yogesh Waman,Anil Panmand,Santosh Kumar,Sachin Thorat,Minakshi Naykodi,Arnab Goswami,B. Srinivasa Reddy,Vandna Prasad,Sandhya Chaturvedi,Azfar Quraishi,Suraj Menon,Shalini Paliwal,Abhay Kulkarni,Vikas Karande,Indraneel Ghosh,Syed Mustafa,Siddhartha De,Vaibhav Jain,Ena Ray Banerjee,Sreekanth R. Rouduri,Venkata P. Palle,Anita Chugh,Kasim A. Mookhtiar +26 more
TL;DR: Several prop-2-ynylated C8-aryl or heteroaryl substitutions on xanthine chemotype were explored and found that 1-prop-2 -ynyl-1H-pyrazol-4-yl moiety was better tolerated at the C8 position and provided better selectivity for A2BAdoR compared to that of para-substituted analogs.
Journal ArticleDOI
Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors
Sujay Basu,Uppuleti Viplava Prasad,Dinesh A. Barawkar,Siddhartha De,Venkata P. Palle,Suraj Menon,Meena Patel,Sachin Thorat,Umesh Prasad Singh,Koushik Das Sarma,Yogesh Waman,Sanjay Niranjan,Vishal V Pathade,Ashwani Gaur,Satyanarayana Reddy,Shariq S. Ansari +15 more
TL;DR: A series of novel heterocyclic carboxylic acid based protein tyrosine phosphatase 1B (PTP1B) inhibitors with hydrophobic tail showed favorable cell permeability and pharmacokinetic properties in mouse with moderate to very good oral bio-availability.
Journal ArticleDOI
A2B adenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives.
Sujay Basu,Dinesh A. Barawkar,Vidya Ramdas,Yogesh Waman,Meena Patel,Anil Panmand,Santosh Kumar,Sachin Thorat,Rajesh Bonagiri,Dilip Jadhav,Partha P. Mukhopadhyay,Vandna Prasad,B. Srinivasa Reddy,Arnab Goswami,Sandhya Chaturvedi,Suraj Menon,Azfar Quraishi,Indraneel Ghosh,Sushant Dusange,Shalini Paliwal,Abhay Kulkarni,Vikas Karande,Rhishikesh Thakre,Gaurav Bedse,Sreekanth R. Rouduri,Jayasagar Gundu,Venkata P. Palle,Anita Chugh,Kasim A. Mookhtiar +28 more
TL;DR: SAR optimization resulted in identification of two novel A2BAdoR antagonists, 8-{1-[5-Oxo-1-(4-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-xanthine (31) and 8-1-{2- Oxo-2-[4-(3- Trif
Journal ArticleDOI
Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation
Sujay Basu,Dinesh A. Barawkar,Sachin Thorat,Yogesh D. Shejul,Meena Patel,Minakshi Naykodi,Vaibhav Jain,Yogesh Salve,Vandna Prasad,Sumit Chaudhary,Indraneel Ghosh,Ganesh Bhat,Azfar Quraishi,Harish Patil,Shariq S. Ansari,Suraj Menon,Vishal Unadkat,Rhishikesh Thakare,Madhav S. Seervi,Ashwinkumar V. Meru,Siddhartha De,Ravi K. Bhamidipati,Sreekanth R. Rouduri,Venkata P. Palle,Anita Chug,Kasim A. Mookhtiar +25 more
TL;DR: Optimization using structure-based drug design approach resulted in discovery of potent and selective adenosine A2A receptor antagonists bearing substituted 1-methylcyclohexyl-carboxamide groups at position 2 of the benzothiazole scaffold and endowed with better solubility and oral bioavailability.
Journal ArticleDOI
Discovery of Potent and Selective A2A Antagonists with Efficacy in Animal Models of Parkinson’s Disease and Depression
Sujay Basu,Dinesh A. Barawkar,Vidya Ramdas,Minakshi Naykodi,Yogesh D. Shejul,Meena Patel,Sachin Thorat,Anil Panmand,K. Kashinath,Rajesh Bonagiri,Vandna Prasad,Ganesh Bhat,Azfar Quraishi,Sumit Chaudhary,Amol Magdum,Ashwinkumar V. Meru,Indraneel Ghosh,Ravi K. Bhamidipati,Amol A. Raje,Vamsi Madgula,Siddhartha De,Sreekanth R. Rouduri,Venkata P. Palle,Anita Chugh,Narayanan Hariharan,Kasim A. Mookhtiar +25 more
TL;DR: A novel series of [1,2,4]triazolo[5,1-f]purin-2-one derivatives that displays functional antagonism of the A2A receptor with a high degree of selectivity over A1, A2B, and A3 receptors are described.