A
Arnab Goswami
Researcher at Post Graduate Institute of Medical Education and Research
Publications - 5
Citations - 63
Arnab Goswami is an academic researcher from Post Graduate Institute of Medical Education and Research. The author has contributed to research in topics: Xanthine & Adenosine receptor. The author has an hindex of 4, co-authored 4 publications receiving 47 citations.
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Journal ArticleDOI
Design and synthesis of novel xanthine derivatives as potent and selective A 2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases.
Sujay Basu,Dinesh A. Barawkar,Vidya Ramdas,Meena Patel,Yogesh Waman,Anil Panmand,Santosh Kumar,Sachin Thorat,Minakshi Naykodi,Arnab Goswami,B. Srinivasa Reddy,Vandna Prasad,Sandhya Chaturvedi,Azfar Quraishi,Suraj Menon,Shalini Paliwal,Abhay Kulkarni,Vikas Karande,Indraneel Ghosh,Syed Mustafa,Siddhartha De,Vaibhav Jain,Ena Ray Banerjee,Sreekanth R. Rouduri,Venkata P. Palle,Anita Chugh,Kasim A. Mookhtiar +26 more
TL;DR: Several prop-2-ynylated C8-aryl or heteroaryl substitutions on xanthine chemotype were explored and found that 1-prop-2 -ynyl-1H-pyrazol-4-yl moiety was better tolerated at the C8 position and provided better selectivity for A2BAdoR compared to that of para-substituted analogs.
Journal ArticleDOI
A2B adenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives.
Sujay Basu,Dinesh A. Barawkar,Vidya Ramdas,Yogesh Waman,Meena Patel,Anil Panmand,Santosh Kumar,Sachin Thorat,Rajesh Bonagiri,Dilip Jadhav,Partha P. Mukhopadhyay,Vandna Prasad,B. Srinivasa Reddy,Arnab Goswami,Sandhya Chaturvedi,Suraj Menon,Azfar Quraishi,Indraneel Ghosh,Sushant Dusange,Shalini Paliwal,Abhay Kulkarni,Vikas Karande,Rhishikesh Thakre,Gaurav Bedse,Sreekanth R. Rouduri,Jayasagar Gundu,Venkata P. Palle,Anita Chugh,Kasim A. Mookhtiar +28 more
TL;DR: SAR optimization resulted in identification of two novel A2BAdoR antagonists, 8-{1-[5-Oxo-1-(4-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-xanthine (31) and 8-1-{2- Oxo-2-[4-(3- Trif
Journal ArticleDOI
Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate
Vidya Ramdas,Rashmi Talwar,Moloy Banerjee,Advait Arun Joshi,Amit Kumar Das,Deepak Sahebrao Walke,Prashant Borhade,Usha Dhayagude,Rajesh Loriya,Ganesh Navinchandra Gote,Apparao Bommakanti,Aruna Sivaram,Gautam Agarwal,Arnab Goswami,Prashant B. Nigade,Maneesh Mehta,Vinod Patil,Dipak Modi,Hemant Kumar,Sadanand Mallurwar,Amruta Dash,Falguni Modi,Sandip Kuldharan,Pratima Srivastava,M. K. Singh,Lakshmi Narasimham,Jayasagar Gundu,Sharad Sharma,Rajender Kumar Kamboj,Venkata P. Palle +29 more
TL;DR: The newly identified compounds 12, 16, 19-21 have shown desirable pharmacokinetic profile with a favorable uptake of compounds in liver and maintained a significant concentration for up to 8h in the liver.
Journal Article
Spontaneous bacterial abscess of corpus cavernosum
Journal ArticleDOI
A Statistically Validated Electrochemical (Conductometric) and Spectroscopical Study of Some Metal Ligand Complexes for Prospective Biological Action
Anindya Bagchi,Anusree Raha,Prosenjit Mukherjee,Monit Pal,Kunal Datta,Arnab Goswami,Paramita Karmakar,Diptendu Sekhar Biswas,Reshmi Mukherjee +8 more
TL;DR: In this paper , an electrochemical study dealing with the evaluation of a complexation process involving different metal and ligands and its physicochemical properties to find out the ligand- metal ratio of complex in solution.