Abhijeet Kumar

TL;DR: Molecular docking studies using 10 potential naturally occurring compounds against the SARS-CoV-2 spike protein and compared their affinity with an FDA approved repurposed drug hydroxychloroquine revealed that these molecules bind with the hACE2-S complex with low binding free energy, and ADME analysis suggested that they consist of drug-likeness property, which may be further explored as anti-SARS- CoV- 2 agents.

TL;DR: These flavonoid and non-flavonoid moieties have significantly high binding affinity for the two main important domains of the spike protein which is responsible for the attachment and internalization of the virus in the host cell and their binding affinities are much higher compared to that of HCQ.

TL;DR: Pyrimidine derivative AP-NP may be explored as an effective inhibitor for hACE2-S complex and in vitro and in vivo studies will strengthen the use of these inhibitors as suitable drug candidates against SARS-COV-2.

TL;DR: In this paper, cross-coupling reactions of differently substituted 4-chlorocoumarins were studied under palladium catalysis using triarylbismuths as threefold arylating reagents.

TL;DR: P palladium-catalyzed reactions afforded chemo-selective C-4 arylations with the facile formation of 3-bromo-4-arylcoumarins in good to high yields.