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Abigail E. Overacre
Researcher at University of Tennessee Health Science Center
Publications - 7
Citations - 727
Abigail E. Overacre is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: FOXP3 & Cholinergic neuron. The author has an hindex of 6, co-authored 7 publications receiving 615 citations. Previous affiliations of Abigail E. Overacre include University of Oklahoma & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
Greg M. Delgoffe,Seng-Ryong Woo,Meghan E. Turnis,David M. Gravano,Cliff Guy,Abigail E. Overacre,Abigail E. Overacre,Matthew L. Bettini,Peter Vogel,David Finkelstein,Jody Bonnevier,Creg J. Workman,Dario A. A. Vignali +12 more
TL;DR: The data support a model in which Treg-cell stability can be subverted in certain inflammatory sites, but is maintained by a Sema4a–Nrp1 axis, highlighting this pathway as a potential therapeutic target that could limit TReg-cell-mediated tumour-induced tolerance without inducing autoimmunity.
Journal ArticleDOI
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
Clifford S. Guy,Kate M. Vignali,Jamshid Temirov,Matthew L. Bettini,Abigail E. Overacre,Matthew P. Smeltzer,Hui Zhang,Johannes B. Huppa,Yu Hwai Tsai,Camille Lobry,Jianming Xie,Peter J. Dempsey,Howard C. Crawford,Iannis Aifantis,Mark M. Davis,Dario A. A. Vignali +15 more
TL;DR: The T CR-driven pathways that initiate cytokine secretion and proliferation are separable and are coordinated by the multiplicity of phosphorylated ITAMs in TCR-CD3.
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Treg stability: to be or not to be
TL;DR: How T(reg) stability is defined and the mechanisms utilized to maintain stability are discussed and additional studies may help to define approaches that can undermine or enhance T(Reg) stability in transplantation, autoimmune or inflammatory diseases and therefore have substantial therapeutic utility.
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Effects of antidepressant treatment on mice lacking brain-derived neurotrophic factor expression through promoter IV.
Kazuko Sakata,Joshua R. Mastin,Sean M. Duke,Meghan G. Vail,Abigail E. Overacre,Brittany E. Dong,Shanker Jha +6 more
TL;DR: The results indicate that the behavioral effects in the tail suspension test by antidepressants do not require promoter IV‐driven BDNF expression and occur without a detectable increase in hippocampal BDNF levels and neurogenesis but may involve increased dendritic reorganisation of immature neurons.
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Effects of salt, polyethylene glycol, and locked nucleic acids on the thermodynamic stabilities of consecutive terminal adenosine mismatches in RNA duplexes.
TL;DR: The ability of RNA duplexes to form extended terminal mismatches in the absence of proteins such as argonaute and identifying the enthalpic contributions to terminal mismatch stabilities provide insight into the physical basis of microRNA-mRNA molecular recognition and specificity.