J
Jody Bonnevier
Researcher at University of Minnesota
Publications - 21
Citations - 696
Jody Bonnevier is an academic researcher from University of Minnesota. The author has contributed to research in topics: Flow cytometry & T cell. The author has an hindex of 8, co-authored 19 publications receiving 605 citations. Previous affiliations of Jody Bonnevier include Medical College of Wisconsin.
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Journal ArticleDOI
Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
Greg M. Delgoffe,Seng-Ryong Woo,Meghan E. Turnis,David M. Gravano,Cliff Guy,Abigail E. Overacre,Abigail E. Overacre,Matthew L. Bettini,Peter Vogel,David Finkelstein,Jody Bonnevier,Creg J. Workman,Dario A. A. Vignali +12 more
TL;DR: The data support a model in which Treg-cell stability can be subverted in certain inflammatory sites, but is maintained by a Sema4a–Nrp1 axis, highlighting this pathway as a potential therapeutic target that could limit TReg-cell-mediated tumour-induced tolerance without inducing autoimmunity.
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Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo
Traci Zell,Alexander Khoruts,Elizabeth Ingulli,Jody Bonnevier,Daniel L. Mueller,Marc K. Jenkins +5 more
TL;DR: The remarkable rapidity of this response correlated with the finding that most naive T cells are in constant contact with dendritic antigen-presenting cells, and highlights the efficiency of the in vivo immune response.
Journal ArticleDOI
Cutting Edge: B7/CD28 Interactions Regulate Cell Cycle Progression Independent of the Strength of TCR Signaling
Jody Bonnevier,Daniel L. Mueller +1 more
TL;DR: A synergy does exist between TCR and CD28 signaling in the initial activation of the T cells, but unlike the TCR, the strength of CD28 stimulation was also shown to play a unique role in controlling the rate of cell division by T cell blasts.
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CD28 signaling augments Elk-1-dependent transcription at the c-fos gene during antigen stimulation.
Wei Li,Carmella D. Whaley,Jody Bonnevier,Anna Mondino,Molly E. Martin,Kjersti Aagaard-Tillery,Daniel L. Mueller +6 more
TL;DR: A unique role for B7 costimulatory molecules and CD28 in the activation of JNK during Ag stimulation in Th1 cells is identified, and it is suggested that JNK regulates Elk-1 transactivation at the c-fos gene to promote the formation of AP-1 complexes important to IL-2 gene expression.
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Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays.
Jodi Hagen,Ryan Zimmerman,Christine Goetz,Jody Bonnevier,Jeffrey P. Houchins,Kevin Reagan,Alexander E. Kalyuzhny +6 more
TL;DR: The data indicate that ELISPOT, ELISA and flow cytometry should be performed as complementary, rather than stand-alone assays: running these assays in parallel on samples from the same donors may help to better understand the mechanisms underlying the physiology of cytokine-secreting cells.