M
Matthew L. Bettini
Researcher at Baylor College of Medicine
Publications - 34
Citations - 2689
Matthew L. Bettini is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 15, co-authored 27 publications receiving 2229 citations. Previous affiliations of Matthew L. Bettini include Emory University & St. Jude Children's Research Hospital.
Papers
More filters
Journal ArticleDOI
Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
Seng Ryong Woo,Meghan E. Turnis,Monica V. Goldberg,Jaishree Bankoti,Mark J. Selby,Christopher J. Nirschl,Matthew L. Bettini,David M. Gravano,Peter Vogel,Chih Long Liu,Stephanie Tangsombatvisit,Joseph F. Grosso,George J. Netto,Matthew P. Smeltzer,Alcides Chaux,Paul J. Utz,Creg J. Workman,Drew M. Pardoll,Alan J. Korman,Charles G. Drake,Dario A. A. Vignali +20 more
TL;DR: A strong synergy between the PD-1 and LAG-3 inhibitory pathways in tolerance to both self and tumor antigens is defined and it is argued strongly that dual blockade of these molecules represents a promising combinatorial strategy for cancer.
Journal ArticleDOI
Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
Greg M. Delgoffe,Seng-Ryong Woo,Meghan E. Turnis,David M. Gravano,Cliff Guy,Abigail E. Overacre,Abigail E. Overacre,Matthew L. Bettini,Peter Vogel,David Finkelstein,Jody Bonnevier,Creg J. Workman,Dario A. A. Vignali +12 more
TL;DR: The data support a model in which Treg-cell stability can be subverted in certain inflammatory sites, but is maintained by a Sema4a–Nrp1 axis, highlighting this pathway as a potential therapeutic target that could limit TReg-cell-mediated tumour-induced tolerance without inducing autoimmunity.
Journal ArticleDOI
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
Clifford S. Guy,Kate M. Vignali,Jamshid Temirov,Matthew L. Bettini,Abigail E. Overacre,Matthew P. Smeltzer,Hui Zhang,Johannes B. Huppa,Yu Hwai Tsai,Camille Lobry,Jianming Xie,Peter J. Dempsey,Howard C. Crawford,Iannis Aifantis,Mark M. Davis,Dario A. A. Vignali +15 more
TL;DR: The T CR-driven pathways that initiate cytokine secretion and proliferation are separable and are coordinated by the multiplicity of phosphorylated ITAMs in TCR-CD3.
Journal ArticleDOI
Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency
Matthew L. Bettini,Fan Pan,Maria Bettini,David Finkelstein,Jerold E. Rehg,Stefan Floess,Bryan D. Bell,Steven F. Ziegler,Jochen Huehn,Drew M. Pardoll,Dario A. A. Vignali +10 more
TL;DR: It is shown that a well-characterized Foxp3(gfp) reporter mouse, which expresses an N-terminal GFP-Foxp3 fusion protein, is a hypomorph that causes profoundly accelerated autoimmune diabetes on a NOD background.
Journal ArticleDOI
Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses.
Myunghoo Kim,Carolina Galan,Andrea A. Hill,Wan-Jung Wu,Hannah Fehlner-Peach,Hyo Won Song,Deborah Schady,Matthew L. Bettini,Kenneth W. Simpson,Randy S. Longman,Dan R. Littman,Gretchen E. Diehl +11 more
TL;DR: It is demonstrated that microbial adhesion to intestinal epithelium helps regulate the balance between pro‐ and anti‐inflammatory T cell responses through induction of IL‐10 by a subset of intestinal antigen‐presenting cells.