A
Abrahan Hernández-Hernández
Researcher at Karolinska Institutet
Publications - 28
Citations - 924
Abrahan Hernández-Hernández is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Synaptonemal complex & Meiosis. The author has an hindex of 13, co-authored 26 publications receiving 723 citations. Previous affiliations of Abrahan Hernández-Hernández include National Autonomous University of Mexico.
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Journal ArticleDOI
A Novel Mouse Synaptonemal Complex Protein Is Essential for Loading of Central Element Proteins, Recombination, and Fertility
Sabine Schramm,Johanna Fraune,Ronald Naumann,Abrahan Hernández-Hernández,Christer Höög,Howard J. Cooke,Howard J. Cooke,Manfred Alsheimer,Ricardo Benavente +8 more
TL;DR: It is found that SYCE3 is required for fertility in both sexes and enables chromosome loading of the other CE–specific proteins, which in turn would promote synapsis between homologous chromosomes.
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Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes
Kei-ichiro Ishiguro,Jihye Kim,Hiroki Shibuya,Abrahan Hernández-Hernández,Aussie Suzuki,Tatsuo Fukagawa,Go Shioi,Hiroshi Kiyonari,Xin Chenglin Li,John C. Schimenti,Christer Höög,Yoshinori Watanabe +11 more
TL;DR: It is shown that homolog recognition or association initiates upon entry into meiotic prophase before axis assembly and double-strand break (DSB) formation, suggesting the intriguing possibility that homology recognition is achieved primarily by searching for homology in the chromosome architecture as defined by meiosis-specific cohesin rather than in the DNA sequence itself.
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MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.
Hiroki Shibuya,Abrahan Hernández-Hernández,Akihiro Morimoto,Lumi Negishi,Christer Höög,Yoshinori Watanabe +5 more
TL;DR: A positive feedback between telomere attachment and chromosome movement is uncovered, revealing a comprehensive regulatory network underlying meiosis-specific telomeres function in mammals.
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STAG3‐mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis
Tomoyuki Fukuda,Tomoyuki Fukuda,Nanaho Fukuda,Ana Agostinho,Abrahan Hernández-Hernández,Anna Kouznetsova,Christer Höög +6 more
TL;DR: It is found that the three different α‐kleisins present in meiotic cells show different dosage‐dependent requirements for STAG3 and thatSTAG3‐REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions.
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Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.
Yuval Tabach,Tamar Golan,Abrahan Hernández-Hernández,Arielle R. Messer,Tomoyuki Fukuda,Anna Kouznetsova,Jian‐Guo Liu,Ingrid Lilienthal,Carmit Levy,Gary Ruvkun +9 more
TL;DR: Focusing on proteins coevolved with the microphthalmia‐associated transcription factor (MITF), the Notch pathway suppressor of hairless (RBP‐Jk/SuH) transcription factor is identified, and it is shown that RBP‐JK functions as an MITF cofactor.