A
Achintya Saha
Researcher at University of Calcutta
Publications - 149
Citations - 2009
Achintya Saha is an academic researcher from University of Calcutta. The author has contributed to research in topics: Pharmacophore & Quantitative structure–activity relationship. The author has an hindex of 20, co-authored 136 publications receiving 1587 citations.
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Exploring quantitative structure–activity relationship studies of antioxidant phenolic compounds obtained from traditional Chinese medicinal plants
TL;DR: The QSAR models developed here can be utilised for the antioxidant activity prediction of a new series of molecules, indicating the predictivity and robustness, respectively, of the developed models.
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Rosmarinic Acid Attenuates Cadmium-Induced Nephrotoxicity via Inhibition of Oxidative Stress, Apoptosis, Inflammation and Fibrosis
Swarnalata Joardar,Saikat Dewanjee,Shovonlal Bhowmick,Tarun K. Dua,Sonjit Das,Achintya Saha,Vincenzo De Feo +6 more
TL;DR: RA exhibited a concentration-dependent anti-apoptotic effect against CdCl2 in isolated mouse proximal tubular epithelial cells and can potentially be applied as a therapeutic agent to treat Cd-mediated nephrotoxicity in future.
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Protocatechuic acid, a phenolic from sansevieria roxburghiana leaves, suppresses diabetic cardiomyopathy via stimulating glucose metabolism, ameliorating oxidative stress, and inhibiting inflammation
Niloy Bhattacharjee,Tarun K. Dua,Ritu Khanra,Swarnalata Joardar,Ashis Nandy,Achintya Saha,Vincenzo De Feo,Saikat Dewanjee +7 more
TL;DR: Results would suggest a possibility of protocatechuic acid to be a new therapeutic agent for DC in future, and in silico ADME study predicted that protocatechinic acid would support the drug-likeness character.
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Design of dual MMP-2/HDAC-8 inhibitors by pharmacophore mapping, molecular docking, synthesis and biological activity
TL;DR: Dual MMP-2/HDAC-8 inhibitors designed by pharmacophore mapping and molecular docking approaches have considerable anti-migratory and anti-invasive properties and may help to obtain some useful dual inhibitors.
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Arylsulfonamides and selectivity of matrix metalloproteinase-2: An overview.
TL;DR: Arylsulfonamides have been highlighted as potential and selective MMP-2 inhibitors through structure-activity relationships study and it may be postulated that sulfonamide moiety may provide better direction to the associated aryl group to accommodate the deep hydrophobic S1' pocket.