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Adam Claridge-Chang
Researcher at National University of Singapore
Publications - 60
Citations - 3566
Adam Claridge-Chang is an academic researcher from National University of Singapore. The author has contributed to research in topics: Optogenetics & Biology. The author has an hindex of 17, co-authored 53 publications receiving 2707 citations. Previous affiliations of Adam Claridge-Chang include Institute of Molecular and Cell Biology & Yale University.
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Journal ArticleDOI
Moving beyond P values: data analysis with estimation graphics
Joses Ho,Tayfun Tumkaya,Tayfun Tumkaya,Sameer Aryal,Sameer Aryal,Hyungwon Choi,Hyungwon Choi,Adam Claridge-Chang,Adam Claridge-Chang +8 more
TL;DR: The estimation graphic is described, a plot that displays an experimental dataset’s complete statistical information that avoids dichotomous thinking and introduces software that makes high-quality estimation graphics available to all.
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Writing Memories with Light-Addressable Reinforcement Circuitry
Adam Claridge-Chang,Robert D. Roorda,Eleftheria Vrontou,Lucas Sjulson,Haiyan Li,Jay Hirsh,Gero Miesenböck +6 more
TL;DR: By optically controlling genetically circumscribed subsets of dopaminergic neurons in the behaving fly, this work has mapped the origin of aversive reinforcement signals to the PPL1 cluster of 12 dopamine cells.
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Circadian regulation of gene expression systems in the Drosophila head
Adam Claridge-Chang,Herman Wijnen,Felix Naef,Catharine Boothroyd,Nikolaus Rajewsky,Michael W. Young +5 more
TL;DR: The complement of circadian transcripts in adult Drosophila heads was determined and a subset of 158 genes showed particularly robust cycling and many oscillatory phases, associated with genes involved in diverse biological processes, including learning and memory/synapse function.
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Excitatory Local Circuits and Their Implications for Olfactory Processing in the Fly Antennal Lobe
TL;DR: A previously unidentified population of cholinergic local neurons (LNs) with multiglomerular processes that respond broadly to odors but exhibit little glomerular specificity in their synaptic output are described, suggesting that PNs are driven by a combination of glomerulus-specific ORN afferents and diffuse LN excitation.
Journal ArticleDOI
Optogenetic inhibition of behavior with anion channelrhodopsins
Farhan Mohammad,James C. Stewart,Stanislav Ott,Katarina Chlebikova,Jia Yi Chua,Tong-Wey Koh,Joses Ho,Adam Claridge-Chang,Adam Claridge-Chang +8 more
TL;DR: It is shown that anion channelrhodopsins can be used to specifically and rapidly inhibit neural systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, thus demonstrating their broad utility in the circuit analysis of behavior.