A
Adam Yongxin Ye
Researcher at Howard Hughes Medical Institute
Publications - 45
Citations - 1213
Adam Yongxin Ye is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 16, co-authored 36 publications receiving 847 citations. Previous affiliations of Adam Yongxin Ye include Boston Children's Hospital & Tsinghua University.
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Journal ArticleDOI
De Novo Insertions and Deletions of Predominantly Paternal Origin Are Associated with Autism Spectrum Disorder
Shan Dong,Shan Dong,Michael F. Walker,Nicholas Carriero,Michael DiCola,A. Jeremy Willsey,A. Jeremy Willsey,Adam Yongxin Ye,Zainulabedin Waqar,Luis E. Gonzalez,John D. Overton,Stephanie Frahm,John F. Keaney,Nicole A. Teran,Jeanselle Dea,Jeffrey D. Mandell,Vanessa H. Bal,Catherine A.W. Sullivan,Nicholas M. DiLullo,Rehab O. Khalil,Jake Gockley,Zafer Yüksel,Sinem M. Sertel,A. Gulhan Ercan-Sencicek,Abha R. Gupta,Shrikant Mane,Michael Sheldon,Andrew Brooks,Kathryn Roeder,Bernie Devlin,Matthew W. State,Liping Wei,Stephen Sanders,Stephen Sanders +33 more
TL;DR: On the basis of mutation rates in probands versus unaffected siblings, it is concluded that de novo frameshift indels contribute to risk in approximately 3% of individuals with ASD.
Journal ArticleDOI
A guide RNA sequence design platform for the CRISPR/Cas9 system for model organism genomes.
TL;DR: A Guide RNA Sequence Design Platform for the Cas9/CRISPR silencing system for model organisms is developed and finds potential targets by PAM and ranks them according to factors including uniqueness, SNP, RNA secondary structure, and AT content.
Journal ArticleDOI
Amplicon Resequencing Identified Parental Mosaicism for Approximately 10% of "de novo" SCN1A Mutations in Children with Dravet Syndrome.
Xiaojing Xu,Xiaoxu Yang,Qixi Wu,Aijie Liu,Xiaoling Yang,Adam Yongxin Ye,Adam Yongxin Ye,August Yue Huang,Jiarui Li,Meng Wang,Zhe Yu,Sheng Wang,Zhichao Zhang,Xiru Wu,Liping Wei,Yuehua Zhang +15 more
TL;DR: The results suggest that more sensitive tools for detecting low‐level mosaicism in parents of families with seemingly “de novo” mutations will allow for better informed genetic counseling.
Journal ArticleDOI
CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning.
Zhaoqing Ba,Zhaoqing Ba,Jiangman Lou,Jiangman Lou,Adam Yongxin Ye,Adam Yongxin Ye,Hai-Qiang Dai,Hai-Qiang Dai,Edward W. Dring,Edward W. Dring,Sherry G. Lin,Sherry G. Lin,Suvi Jain,Suvi Jain,Nia Kyritsis,Nia Kyritsis,Kyong-Rim Kieffer-Kwon,Rafael Casellas,Frederick W. Alt,Frederick W. Alt +19 more
TL;DR: While degradation of CTCF suppressed most CBE-based chromatin interactions, it promoted robust recombination centre interactions with, and robust V H -to-DJ H joining of, distal V H s, with patterns similar to those of ‘locus-contracted’ primary pro-B cells.
Journal ArticleDOI
Profiling the RNA editomes of wild-type C. elegans and ADAR mutants.
Han-Qing Zhao,Pan Zhang,Hua Gao,Xian-Dong He,Yanmei Dou,August Yue Huang,Ximing Liu,Adam Yongxin Ye,Meng-Qiu Dong,Liping Wei +9 more
TL;DR: A new computational pipeline with a "bisulfite-seq-mapping-like" step and a threefold increase in identification sensitivity is developed and revealed a sophisticated landscape of RNA editing and distinct modes of action of different ADARs.