Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury.
Ashish Sharma,Eric J. Charles,Yunge Zhao,Adishesh K. Narahari,Pranav K. Baderdinni,Miranda E. Good,Ulrike Lorenz,Irving L. Kron,Douglas A. Bayliss,Kodi S. Ravichandran,Brant E. Isakson,Victor E. Laubach +11 more
Reads0
Chats0
TLDR
This study is the first, to the authors' knowledge, to demonstrate that endothelial Panx1 plays a key role in mediating vascular permeability, inflammation, edema, leukocyte infiltration, and lung dysfunction after I/R.Abstract:
Ischemia-reperfusion (I/R) injury (IRI), which involves inflammation, vascular permeability, and edema, remains a major challenge after lung transplantation. Pannexin-1 (Panx1) channels modulate ce...read more
Citations
More filters
Journal ArticleDOI
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice.
Kanchan Bisht,Kenneth A. Okojie,Kaushik Sharma,Dennis H. Lentferink,Yu-Yo Sun,Hong-Ru Chen,Joseph O. Uweru,Saipranusha Amancherla,Zainab Calcuttawala,Antony Brayan Campos-Salazar,Bruce A. Corliss,Lara Jabbour,Jordan Benderoth,Bria Friestad,William A. Mills,Brant E. Isakson,Marie-Ève Tremblay,Chia-Yi Kuan,Ukpong B. Eyo +18 more
TL;DR: In this article, the authors show that capillary-associated microglia (CAMs) regulate vascular tone via PANX1-P2RY12 signalling and show that purines released through PANX 1 channels play important roles in activating microglial P2RY 12 receptors to regulate neurovascular structure and function.
Journal ArticleDOI
Mechanisms of obesity-induced metabolic and vascular dysfunctions.
TL;DR: A comprehensive understanding of the mechanisms involved in the development of obesity-induced metabolic and vascular dysfunction is necessary for the identification of more effective and tailored therapeutic avenues for their prevention and treatment.
Journal ArticleDOI
Reactive species-induced microvascular dysfunction in ischemia/reperfusion.
TL;DR: It is now apparent that this microvascular dysfunction is an important determinant of the severity of injury sustained by parenchymal cells in ischemic tissues, as well as being predictive of clinical outcome after reperfusion therapy.
Journal ArticleDOI
Connexins: Key Players in the Control of Vascular Plasticity and Function.
TL;DR: Channel-dependent and -independent roles of connexins in blood vessel function range from basic processes of vascular remodeling and angiogenesis to vascular permeability and interactions with leukocytes with the vessel wall.
Journal ArticleDOI
Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection
Sarah Rosli,Sarah Rosli,Francis J. Kirby,Francis J. Kirby,Kate E. Lawlor,Kate E. Lawlor,Kate Rainczuk,Kate Rainczuk,Grant R Drummond,Ashley Mansell,Ashley Mansell,Michelle D. Tate,Michelle D. Tate +12 more
TL;DR: It is demonstrated that the NLRP3 inflammasome plays time‐dependent roles during severe IAV infection with early protective responses and later dysregulation leading to excessive inflammation, contributing to disease severity.
References
More filters
Journal ArticleDOI
Ischemia and reperfusion—from mechanism to translation
Holger K. Eltzschig,Tobias Eckle +1 more
TL;DR: Ischemia and reperfusion-elicited tissue injury contributes to morbidity and mortality in a wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea as discussed by the authors.
Journal ArticleDOI
Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor
TL;DR: Pannexin‐1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, is identified as this dye‐uptake pathway and signalling through pannexin•1 is required for processing of caspase‐1 and release of mature IL‐1β induced by P2X7 receptor activation.
Journal ArticleDOI
Pannexin membrane channels are mechanosensitive conduits for ATP
TL;DR: Pannexin 1 channels have a wide expression spectrum, they are of large conductance and permeant for ATP, and they are mechanosensitive, Hence, pannexins are candidates for the release of ATP to the extracellular space upon mechanical stress.
Journal ArticleDOI
Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release
TL;DR: It is shown that astrocytes in vitro express functional hemichannels that can mediate robust efflux of glutamate and aspartate and could influence CNS levels of extracellular glutamate with implications for normal and pathological brain function.
Journal ArticleDOI
Purinergic Signaling during Inflammation
TL;DR: Receptors for ATP and ADP and adenosine exert various effects and are emerging as therapeutic targets in a number of inflammatory and autoimmune diseases.
Related Papers (5)
A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Faraaz B. Chekeni,Michael R. Elliott,Michael R. Elliott,Joanna K. Sandilos,Scott F. Walk,Scott F. Walk,Jason M. Kinchen,Jason M. Kinchen,Eduardo R. Lazarowski,Allison Armstrong,Allison Armstrong,Silvia Penuela,Dale W. Laird,Guy S. Salvesen,Brant E. Isakson,Douglas A. Bayliss,Kodi S. Ravichandran,Kodi S. Ravichandran +17 more