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Aditi Murthy
Researcher at Great Ormond Street Hospital for Children NHS Foundation Trust
Publications - 8
Citations - 190
Aditi Murthy is an academic researcher from Great Ormond Street Hospital for Children NHS Foundation Trust. The author has contributed to research in topics: Medicine & Unfolded protein response. The author has an hindex of 1, co-authored 1 publications receiving 103 citations. Previous affiliations of Aditi Murthy include Great Ormond Street Hospital.
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Journal ArticleDOI
Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
L. Al-Olabi,Satyamaanasa Polubothu,Satyamaanasa Polubothu,Katherine Dowsett,Katrina A. Andrews,Paulina Stadnik,Agnel Praveen Joseph,Rachel G. Knox,Rachel G. Knox,Alan Pittman,Graeme R. Clark,W. Baird,Neil W. Bulstrode,M. Glover,Kristiana Gordon,Darren Hargrave,Susan M Huson,Thomas S. Jacques,Gregory James,Hannah C. Kondolf,Loshan Kangesu,Kim M. Keppler-Noreuil,Amjad Khan,Marjorie J. Lindhurst,Mark H. Lipson,Sahar Mansour,Justine O'Hara,Caroline Mahon,Anda Mosica,Celia Moss,Aditi Murthy,Juling Ong,Victoria E. R. Parker,Victoria E. R. Parker,Jean-Baptiste Rivière,Julie C. Sapp,Neil J. Sebire,Rahul Shah,Branavan Sivakumar,Anna C. Thomas,Alex Virasami,Regula Waelchli,Zhiqiang Zeng,Leslie G. Biesecker,Alex M. Barnacle,Maya Topf,Robert K. Semple,Robert K. Semple,Robert K. Semple,E. Elizabeth Patton,Veronica A. Kinsler,Veronica A. Kinsler +51 more
TL;DR: These findings uncover a major cause of sporadic VMs of different clinical types and thereby offer the potential of personalized medical treatment by repurposing existing licensed cancer therapies.
Journal ArticleDOI
Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells
Konstantinos-Dionysios Alysandratos,Carolina Garcia-de-Alba,Changfu Yao,Patrizia Pessina,Jessie Huang,Carlos Villacorta-Martin,O. Hix,Kasey Minakin,C. L. Burgess,Pushpinder Bawa,Aditi Murthy,Bindu Konda,Michael F. Beers,Barry R. Stripp,Carla F. Kim,Darrell N. Kotton +15 more
TL;DR: This article performed head-to-head comparisons among the transcriptomes of primary (1°) adult human alveolar epithelial type 2 cells, their cultured progeny, and human induced pluripotent stem cell-derived AEC2s.
Journal ArticleDOI
Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cells
Jeremy Katzen,Luis R. Rodriguez,Yaniv Tomer,Apoorva Babu,Ming Zhao,Aditi Murthy,Paige Carson,Matthew Barrett,Maria C. Basil,Justine Carl,John Leach,Michael Morley,Matthew D. McGraw,Surafel Mulugeta,Timothy J. Pelura,Glenn Rosen,Edward E. Morrisey,Michael F. Beers +17 more
TL;DR: AEC2 proteostasis, and specifically IRE1α signaling through its major product XBP-1, is identified as a driver of a key AEC2 phenotypic change that has been identified in lung fibrosis.
Journal ArticleDOI
Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with IPF Features.
Luis R. Rodriguez,Yaniv Tomer,Paige Carson,A. Dimopoulos,Ming Zhao,Katrina Chavez,Swati Iyer,Li Huang,Christina Ebert,Larisa Sereda,Aditi Murthy,Glenda Trujillo,Michael F. Beers,Jeremy Katzen +13 more
TL;DR: In this paper , the authors report a refinement of a murine Sftpc mutation model to recapitulate the clinical course, physiological, parenchymal cellular composition, and biomarkers associated with IPF.
Posted ContentDOI
Disruption of Prostaglandin F2α Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary Fibrosis
Luis R. Rodriguez,Soon Yew Tang,Aditi Murthy,Yaniv Tomer,Tian-Quan Cai,Swati Iyer,Katrina Chavez,Soumita Ghosh,A. Dimopoulos,Apoorva Babu,G. Fitzgerald,Michael F. Beers +11 more
TL;DR: In this paper , the authors leveraged the published murine PF model (IER −SftpcI73T) expressing a disease-associated missense mutation in the surfactant protein C (SFTpc) gene.