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Maya Topf
Researcher at Birkbeck, University of London
Publications - 148
Citations - 7247
Maya Topf is an academic researcher from Birkbeck, University of London. The author has contributed to research in topics: Protein structure prediction & Gene. The author has an hindex of 46, co-authored 134 publications receiving 6090 citations. Previous affiliations of Maya Topf include Heinrich Pette Institute & Australian National University.
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Critical assessment of methods of protein structure prediction (CASP)-Round XIII
TL;DR: The most recent Critical Assessment of Structure Prediction (CASP13) as discussed by the authors assesses the state of the art in modeling protein structure from amino acid sequence, and the results showed dramatic improvements in three-dimensional structure accuracy.
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Protein structure fitting and refinement guided by cryo-EM density.
TL;DR: A heuristic optimization that relies on a Monte Carlo search, a conjugate-gradients minimization, and simulated annealing molecular dynamics is applied to a series of subdivisions of the structure into progressively smaller rigid bodies.
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A structural perspective on protein-protein interactions.
Robert B. Russell,Robert B. Russell,Frank Alber,Patrick Aloy,Fred P. Davis,Dmitry Korkin,Matthieu Pichaud,Maya Topf,Andrej Sali +8 more
TL;DR: Structures of macromolecular complexes are necessary for a mechanistic description of biochemical and cellular processes and can be solved by experimental methods, as well as by computational protein structure prediction, docking and bioinformatics.
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Integrating diverse data for structure determination of macromolecular assemblies.
TL;DR: An approach to integrate structural information gathered at multiple levels of the biological hierarchy--from atoms to cells--into a common framework is proposed, illustrated by determining the configuration of the 456 proteins in the nuclear pore complex from baker's yeast.
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Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
L. Al-Olabi,Satyamaanasa Polubothu,Satyamaanasa Polubothu,Katherine Dowsett,Katrina A. Andrews,Paulina Stadnik,Agnel Praveen Joseph,Rachel G. Knox,Rachel G. Knox,Alan Pittman,Graeme R. Clark,W. Baird,Neil W. Bulstrode,M. Glover,Kristiana Gordon,Darren Hargrave,Susan M Huson,Thomas S. Jacques,Gregory James,Hannah C. Kondolf,Loshan Kangesu,Kim M. Keppler-Noreuil,Amjad Khan,Marjorie J. Lindhurst,Mark H. Lipson,Sahar Mansour,Justine O'Hara,Caroline Mahon,Anda Mosica,Celia Moss,Aditi Murthy,Juling Ong,Victoria E. R. Parker,Victoria E. R. Parker,Jean-Baptiste Rivière,Julie C. Sapp,Neil J. Sebire,Rahul Shah,Branavan Sivakumar,Anna C. Thomas,Alex Virasami,Regula Waelchli,Zhiqiang Zeng,Leslie G. Biesecker,Alex M. Barnacle,Maya Topf,Robert K. Semple,Robert K. Semple,Robert K. Semple,E. Elizabeth Patton,Veronica A. Kinsler,Veronica A. Kinsler +51 more
TL;DR: These findings uncover a major cause of sporadic VMs of different clinical types and thereby offer the potential of personalized medical treatment by repurposing existing licensed cancer therapies.