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Darrell N. Kotton
Researcher at Boston University
Publications - 196
Citations - 13090
Darrell N. Kotton is an academic researcher from Boston University. The author has contributed to research in topics: Induced pluripotent stem cell & Medicine. The author has an hindex of 51, co-authored 148 publications receiving 10494 citations. Previous affiliations of Darrell N. Kotton include Boston Medical Center & Boston Children's Hospital.
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Journal ArticleDOI
Telomere dysfunction induces metabolic and mitochondrial compromise
Ergiin Sahin,Simona Colla,Marc Liesa,Javid Moslehi,Florian L. Muller,Mira Guo,Marcus P. Cooper,Darrell N. Kotton,Attila J. Fabian,Carl Walkey,Richard S. Maser,Giovanni Tonon,Friedrich Foerster,Robert Xiong,Y. Alan Wang,Sachet A. Shukla,Mariela Jaskelioff,Eric S. Martin,Timothy P. Heffernan,Alexei Protopopov,Elena Ivanova,John E. Mahoney,Maria Kost-Alimova,Samuel R. Perry,Roderick T. Bronson,Ronglih Liao,Richard C. Mulligan,Orian S. Shirihai,Lynda Chin,Ronald A. DePinho +29 more
TL;DR: It is shown that enforced Tert or PGC-1α expression or germline deletion of p53 substantially restores PGC network expression, mitochondrial respiration, cardiac function and gluconeogenesis in the setting of telomere dysfunction.
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Regeneration and orthotopic transplantation of a bioartificial lung
Harald C. Ott,Ben Clippinger,Claudius Conrad,Christian Schuetz,Irina Pomerantseva,Laertis Ikonomou,Darrell N. Kotton,Joseph P. Vacanti +7 more
TL;DR: Creation of a bioartificial lung requires engineering of viable lung architecture enabling ventilation, perfusion and gas exchange, and regenerated lungs into orthotopic position showed in vivo function.
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Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette
Cesar Sommer,Matthias Stadtfeld,George J. Murphy,Konrad Hochedlinger,Darrell N. Kotton,Gustavo Mostoslavsky +5 more
TL;DR: Using a single lentiviral vector expressing a “stem cell cassette” composed of the four transcription factors and a combination of 2A peptide and internal ribosome entry site technology achieves the most efficient reprogramming system to date and allows derivation of iPS cells with a single viral integration.
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Bone marrow-derived cells as progenitors of lung alveolar epithelium.
Darrell N. Kotton,Bei Yang Ma,Wellington V. Cardoso,Elisabeth A. Sanderson,Ross Summer,Mary C. Williams,Alan Fine +6 more
TL;DR: It is found that cultured and fresh aspirates of bone marrow cells can express the type I pneumocyte markers, T1alpha and aquaporin-5, and raise the possibility of using injected marrow-derived cells for therapy of lung diseases characterized by extensive alveolar damage.
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Generation of Transgene‐Free Lung Disease‐Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette
Aba Somers,Jyh-Chang Jean,Cesar Sommer,Amel Omari,Christopher C. Ford,Jason A. Mills,Lei Ying,Andreia Gianotti Sommer,Jenny M. Jean,Brenden W. Smith,Robert Lafyatis,Marie-France Demierre,Daniel J. Weiss,Deborah L. French,Paul Gadue,George J. Murphy,Gustavo Mostoslavsky,Darrell N. Kotton +17 more
TL;DR: It is demonstrated that human iPSC generated with the use of a humanized version of a single lentiviral “stem cell cassette” vector have the ability to robustly differentiate into definitive endoderm in vitro, the developmental precursor tissue of lung epithelia.