Adrian A. Canutescu

TL;DR: A new algorithm forSCWRL is presented that uses results from graph theory to solve the combinatorial problem encountered in the side‐chain prediction problem, and will allow for use of SCWRL in more demanding applications such as sequence design and ab initio structure prediction, as well addition of a more complex energy function and conformational flexibility, leading to increased accuracy.

TL;DR: Analysis of composition and mode of assembly of SAHF indicates that HIRA and ASF1a drive formation of macroH2A-containing SAHF and senescence-associated cell cycle exit, via a pathway that appears to depend on flux of heterochromatic proteins through PML bodies.

TL;DR: An algorithm developed originally for inverse kinematics applications in robotics, referred to as cyclic coordinate descent or CCD, involves adjusting one dihedral angle at a time to minimize the sum of the squared distances between three backbone atoms of the moving C‐terminal anchor and the corresponding atoms in the fixed C‐ terminal anchor.

TL;DR: SCWRL and MolIDE are software applications for prediction of protein structures designed specifically for the task of prediction of side-chain conformations given a fixed backbone usually obtained from an experimental structure determined by X-ray crystallography or NMR.

TL;DR: The crystal structure of an ASF1a–HIRA heterodimer and a biochemical dissection of ASF 1a's mutually exclusive interactions with HIRA and the p60 subunit of CAF-1 begin to define the molecular determinants of assembly of functionally diverse macromolecular histone chaperone complexes.