Showing papers in "Developmental Cell in 2005"

TL;DR: The results demonstrate that beta-catenin is essential in determining whether mesenchymal progenitors will become osteoblasts or chondrocytes regardless of regional locations or ossification mechanisms.

TL;DR: Findings demonstrate that beta-catenin, and presumably Wnt signaling, promote the ability of differentiated osteoblasts to inhibit osteoclast differentiation and broaden the knowledge of the functions Wnt proteins have at various stages of skeletogenesis.

TL;DR: It is demonstrated that miR172, previously thought to act primarily by translational repression, can efficiently guide mRNA cleavage, although the effects on steady-state levels of target transcripts are obscured by strong feedback regulation.

TL;DR: Molecular insights into how reduced oxygen levels control the cellular differentiation status are provided and a role for Notch is demonstrated in this process.

TL;DR: It is shown by conditionally deleting beta-catenin in limb and head mesenchyme that beta- catenin is required for osteoblast lineage differentiation, preventing transdifferentiation of osteoblastic cells into chondrocytes.

TL;DR: It is shown that three additional F box proteins, called AFB1, 2, and 3, also regulate auxin response and collectively mediate auxin responses throughout plant development.

TL;DR: It is shown that Wnt9b is expressed in the inductive epithelia and is essential for the development of mesonephric and metanephric tubules and caudal extension of the Müllerian duct, and this data implicate canonical Wnt signaling as one of the major pathways in the organization of the mammalian urogenital system.

TL;DR: Analysis of composition and mode of assembly of SAHF indicates that HIRA and ASF1a drive formation of macroH2A-containing SAHF and senescence-associated cell cycle exit, via a pathway that appears to depend on flux of heterochromatic proteins through PML bodies.

TL;DR: The ability of BAR and F-BAR domain proteins to induce tubular invaginations of the plasma membrane is enhanced by disruption of the actin cytoskeleton and is antagonized by dynamin, suggesting a close interplay between the mechanisms that control actin dynamics and those that mediate plasma membrane invagination and fission.

TL;DR: In this paper, the mouse placenta functions as a hematopoietic organ that harbors a large pool of pluripotent HSCs during midgestation.

TL;DR: A major role is revealed for Ubc9, and, by implication, for the SUMO pathway, in nuclear architecture and function, chromosome segregation, and embryonic viability in mammals.

TL;DR: Genetic analysis indicates that mir-48, mir-84, and mir-241 specify the timing of the L2-to-L3 transition in parallel to the heterochronic genes lin-28 and lin-46, indicating that let-7 family microRNAs function in combination to affect both early and late developmental timing decisions.

TL;DR: It is proposed that MAX1 acts on a mobile substrate, downstream of MAX3 and MAX4, which have immobile substrates, and that the proposed enzymatic series for MAX hormone synthesis resembles that of two already characterized signal biosynthetic pathways: prostaglandins in animals and oxilipins in plants.

TL;DR: It is demonstrated here that the placenta also harbors adult-repopulating HSCs, and placental cell expression of other HSC markers and transcription factors suggests that HSC emergence may occur in the Placenta, as has been proposed for other embryonic hematopoietic sites.

TL;DR: This study utilizes RNA-mediated genetic interference (RNAi) to introduce large-scale gene inhibition studies to the classic planarian system and establishes planarians as a powerful model for the molecular genetic study of stem cells, regeneration, and tissue homeostasis.

TL;DR: This article showed that the hair follicular epithelium is derived from cells in the epidermal placode that express Sonic hedgehog and that the stem cells resident in the follicular bulge that regenerate the follicle are neither the source of the Epidermis nor the source in the absence of trauma.

TL;DR: These findings demonstrate that abu-11 and other members of its ER stress gene family are positive determinants of C. elegans life span and that resveratrol extends life span by inhibiting sir-2.1-mediated repression of ER stress genes.

TL;DR: This work identifies an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein, which plays a crucial role in the formation of stress fibers and lamellipodia.

TL;DR: It is proposed that these proteins polarize trafficking of Cadherin-containing exocyst vesicles during junction remodeling, which may be a common mechanism for the action of planar cell polarity proteins in diverse systems.

TL;DR: It is shown that "rescued" null sperm were not hyperactive, displayed flagellar angulation, and remained unable to fertilize eggs in vitro, uncover a requirement for sAC during spermatogenesis and/or epididymal maturation and reveal limitations inherent in studying sAC function using knockout mice.

TL;DR: Evidence that Slug/Snail, in the presence of Sox9, is sufficient to induce an EMT in neural epithelial cells, while FoxD3 regulates the expression of cell-cell adhesion molecules required for neural crest migration is provided.

TL;DR: Gene knockdown experiments and transplantation assays demonstrated the reciprocal negative regulation of pu.1 and gata1 and their non-cell-autonomous regulation that determines myeloid versus erythroid MPC fate in the distinct blood-forming regions, providing intriguing evidence that this gene can function in the absence of some stem cell genes, such as scl, in governing myelopoiesis.

TL;DR: It is shown that endocardial and epicardial derived FGF signals regulate myocardial proliferation during midgestation heart development and that this FGF signal is received by both FGF receptors 1 and 2 acting redundantly in the cardiomyoblast.

TL;DR: Vps25, a component of the ESCRT machinery that regulates endocytic sorting of signaling receptors, is identified as an unconventional type of Drosophila tumor suppressor.

TL;DR: The function of Spry1 is to modulate GDNF/RET signaling in the Wolffian duct, ensuring that kidney induction is restricted to a single site and demonstrating the importance of negative feedback regulation of RTK signaling during kidney induction.

TL;DR: The chick embryo has a long and distinguished history as a major model system in developmental biology and has also contributed major concepts to immunology, genetics, virology, cancer, and cell biology, which has become even more powerful thanks to several new technologies.

TL;DR: It is shown that zebrafish embryos mutant in the Hh pathway or treated with the HH signaling inhibitor cyclopamine display defects in adult hematopoietic stem cell (HSC) formation but not in primitive hematoiesis.

TL;DR: WNT and FGF8 signals act in parallel at the neural border and converge on Pax3 activity during neural crest induction, which is required for neural crest formation and display overlapping but nonidentical activities.

TL;DR: It is shown that REC8 has an essential role in mammalian meiosis, in that Rec8 null mice of both sexes have germ cell failure and are sterile, and that early chromosome pairing events appear normal, but synapsis occurs in a novel fashion: between sister chromatids.

TL;DR: It is found that the Drosophila gene vps25 possesses several properties of a tumor suppressor, and a possible role for ESCRT components in human cancer is suggested.