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Adrian Bekier
Researcher at University of Łódź
Publications - 14
Citations - 150
Adrian Bekier is an academic researcher from University of Łódź. The author has contributed to research in topics: Chemistry & Toxoplasma gondii. The author has an hindex of 6, co-authored 8 publications receiving 59 citations.
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Journal ArticleDOI
Thiazoles with cyclopropyl fragment as antifungal, anticonvulsant, and anti- Toxoplasma gondii agents: synthesis, toxicity evaluation, and molecular docking study
Krzysztof Z. Łączkowski,Natalia Konklewska,Anna Biernasiuk,Anna Malm,Kinga Sałat,Anna Furgała,Katarzyna Dzitko,Adrian Bekier,Angelika Baranowska-Łączkowska,Agata Paneth +9 more
TL;DR: Thiazoles 3a, 3h, and 3j showed significant anti-Toxoplasma gondii activity, with IC50 values 31–52 times lower than those observed for sulfadiazine, which indicated secreted aspartic proteinase (SAP) as possible antifungal target.
Journal ArticleDOI
Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity
Beata Rosada,Adrian Bekier,Joanna Cytarska,Wojciech Plazinski,Olga Zavyalova,Adam Sikora,Katarzyna Dzitko,Krzysztof Z. Łączkowski +7 more
TL;DR: The results of the cytotoxicity evaluation showed that Toxoplasma gondii growth was inhibited at non-cytotoxic concentrations for the mammalian L929 fibroblast, and the most active compound 3k showed tyrosinase inhibition effect, with IC50 value of 328.5 μM.
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PPE51 Is Involved in the Uptake of Disaccharides by Mycobacterium tuberculosis
Małgorzata Korycka-Machała,Jakub Pawełczyk,Paulina Borówka,Bozena Dziadek,Anna Brzostek,Malwina Kawka,Adrian Bekier,Sebastian Rykowski,Agnieszka B. Olejniczak,Dominik Strapagiel,Zbigniew J. Witczak,Jarosław Dziadek +11 more
TL;DR: It is postulated that PPE51 participates in the uptake of disaccharides by tubercle bacilli as the sole carbon and energy source in spontaneous mutants displaying resistance against the investigated thio-glycoside.
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Systematic Identification of Thiosemicarbazides for Inhibition of Toxoplasma gondii Growth In Vitro.
Agata Paneth,Lidia Węglińska,Adrian Bekier,Edyta Stefaniszyn,Monika Wujec,Nazar Trotsko,Katarzyna Dzitko +6 more
TL;DR: A series of imidazole-thiosemicarbazides with suitable properties for CNS penetration was evaluated and showed much higher potency when compared to sulfadiazine at concentrations that are non-toxic to the host cells, indicating a high selectivity of their anti-toxoplasma activity.
Journal ArticleDOI
Discovery of Potent and Selective Halogen-Substituted Imidazole-Thiosemicarbazides for Inhibition of Toxoplasma gondii Growth In Vitro via Structure-Based Design.
Agata Paneth,Lidia Węglińska,Adrian Bekier,Edyta Stefaniszyn,Monika Wujec,Nazar Trotsko,Anna Hawrył,Mirosław A. Hawrył,Katarzyna Dzitko +8 more
TL;DR: The results of lipophilicity studies collectively suggest that logP would be a rate-limiting factor for the anti-Toxoplasma activity of this class of compounds.