Adrian Biddle

TL;DR: A need to define therapeutic targets that can eradicate both EMT and self-renewing CSC variants to achieve effective SCC treatment is suggested.

TL;DR: Together, these studies drive the emerging notion that cells in a hybrid E/M phenotype may occupy ‘metastatic sweet spot’ in multiple subtypes of carcinomas, and pathways linked to this hybrids may be relevant as prognostic biomarkers as well as a promising therapeutic targets.

TL;DR: Cancer stem cells and their link with EMT are reviewed, and the importance of this link in metastasis and therapeutic resistance of tumours is explored, and new evidence from the laboratory demonstrating that cancer stem cells display a remarkable phenotypic plasticity that enables them to switch between an epithelial phenotype that drives tumour growth and an EMT phenotype that drove metastasis is discussed.

TL;DR: This work evaluated whether low oxygen level affected human adipose tissue mesenchymal stem‐cell phenotype, population growth, viability, apoptosis, necrosis and their adipogenic and osteogenic differentiation potential.

TL;DR: These data indicate that both normal and malignant human epithelial cells with stem-like properties show greater resistance to apoptosis associated with extended G2 cell cycle phase, and that this property is not a consequence of neoplastic transformation.