Nikolaj Dietrich

TL;DR: The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly deregulated in cancer are identified using genome-wide location analysis in human embryonic fibroblasts.

TL;DR: The ability of the oncogene BMI1 to repress the INK4A-ARF locus requires its direct association and is dependent on the continued presence of the EZH2-containing Polycomb-Repressive Complex 2 (PRC2) complex.

TL;DR: This model provides a model to explain how trimethylated Lys 27 of histone 3 (H3K27me3), which is catalysed by the EZH2-containing Polycomb Repressive Complex 2 (PRC2), is maintained in proliferating cells, and suggests that once the H3K 27me3 is established, it recruits the PRC2 complex to maintain the mark at sites of DNA replication, thereby preserving chromatin structure and transcriptional programs.

TL;DR: It is demonstrated that the chromodomain‐containing protein, CBX8, which is part of one of the PRC1 complexes, regulates proliferation of diploid human and mouse fibroblasts through direct binding to the INK4A‐ARF locus.

TL;DR: It is proposed that MSK-mediated H3K27me3S28 phosphorylation serves as a mechanism to activate a subset of PcG target genes determined by the biological stimuli and thereby modulate the gene expression program determining cell fate.