A
Agatha Schwarz
Researcher at University of Kiel
Publications - 91
Citations - 6487
Agatha Schwarz is an academic researcher from University of Kiel. The author has contributed to research in topics: DNA damage & Immune system. The author has an hindex of 42, co-authored 87 publications receiving 6129 citations. Previous affiliations of Agatha Schwarz include University of Münster.
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Journal ArticleDOI
Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes
E Schauer,F Trautinger,A. Köck,Agatha Schwarz,Ranjit Bhardwaj,Manuel M. Simon,John C. Ansel,Thomas Schwarz,T. A. Luger +8 more
TL;DR: Evidence is provided that human keratinocytes produce POMC-derived peptides such as alpha MSH and ACTH, which have been recognized as potent immunomodulatory mediators and may have a major impact on the skin immune system.
Journal ArticleDOI
Ultraviolet-B-induced apoptosis of keratinocytes: evidence for partial involvement of tumor necrosis factor-alpha in the formation of sunburn cells.
Agatha Schwarz,Ranjit Bhardwaj,Yoshinori Aragane,Karsten Mahnke,Helge Riemann,Dieter Metze,Thomas A. Luger,Thomas Schwarz +7 more
TL;DR: In both the in vitro and in vivo systems, application of recombinant TNF-alpha alone either to untreated keratinocytes or into normal murine skin did not induce sunburn cells, which further supports the notion that UVB-induced apoptosis of keratinocyte is a multifactorial event.
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UVA-induced autocrine stimulation of fibroblast-derived collagenase/MMP-1 by interrelated loops of interleukin-1 and interleukin-6.
Meinhard Wlaschek,G. Heinen,Arndt Poswig,Agatha Schwarz,Thomas Krieg,Karin Scharffetter-Kochanek +5 more
TL;DR: A UV‐induced cytokine network consisting of IL–1α,IL–1β andIL–6, which via interrelated autocrine loops induce collagenase/MMP–1 and thus may contribute to the loss of interstitial collagen in cutaneous photoaging is suggested.
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Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
Agatha Schwarz,Sonja Ständer,Mark Berneburg,Markus Böhm,Dagmar Kulms,Harry van Steeg,Karin Grosse-Heitmeyer,Jean Krutmann,Thomas Schwarz +8 more
TL;DR: The results show that cytokines can protect cells from apoptosis induced by DNA-damaging UV radiation by inducing DNA repair, and that nucleotide-excision repair can be manipulated by cytokines.
Journal ArticleDOI
Regulatory T Cells
TL;DR: Detailed knowledge about the phenotype and mode of action of Tregs will significantly increase the understanding of the pathogenesis of autoimmune diseases and will also help to identify new therapeutic strategies.