H
Hagay Sobol
Researcher at Aix-Marseille University
Publications - 185
Citations - 14697
Hagay Sobol is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 53, co-authored 184 publications receiving 13805 citations. Previous affiliations of Hagay Sobol include International Agency for Research on Cancer & University of the Mediterranean.
Papers
More filters
Journal ArticleDOI
Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families
D Ford,Douglas F. Easton,Michael R. Stratton,Steven A. Narod,David E. Goldgar,Peter Devilee,D. T. Bishop,Barbara L. Weber,Gilbert M. Lenoir,Jenny Chang-Claude,Hagay Sobol,M D Teare,Jeffery P. Struewing,Adalgeir Arason,Siegfried Scherneck,Julian Peto,Timothy R. Rebbeck,Patricia N. Tonin,Susan L. Neuhausen,Rosa B. Barkardottir,Jorunn E. Eyfjord,Henry T. Lynch,Bruce A.J. Ponder,Simon A. Gayther,J.M. Birch,Annika Lindblom,Dominique Stoppa-Lyonnet,Y. J. Bignon,Åke Borg,U Hamann,Neva E. Haites,Rodney J. Scott,Christine Maugard,Hans F. A. Vasen,Susanne Seitz,Lisa A. Cannon-Albright,Andrew Craig Schofield,Moraima Zelada-Hedman +37 more
TL;DR: The lifetime risk of breast cancer appears similar to the risk in BRCA1 carriers, but there was some suggestion of a lower risk in bRCA2 carriers <50 years of age.
Journal ArticleDOI
Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome.
Valérie Bonadona,B. Bonaiti,Sylviane Olschwang,Sophie Grandjouan,Laetitia Huiart,Michel Longy,Rosine Guimbaud,Bruno Buecher,Yves-Jean Bignon,Olivier Caron,Chrystelle Colas,Catherine Noguès,Sophie Lejeune-Dumoulin,Laurence Olivier-Faivre,Florence Polycarpe-Osaer,Tan Dat Nguyen,Françoise Desseigne,Jean-Christophe Saurin,Pascaline Berthet,Dominique Leroux,Jacqueline Duffour,Sylvie Manouvrier,Thierry Frebourg,Hagay Sobol,Christine Lasset,Catherine Bonaïti-Pellié +25 more
TL;DR: MSH6 mutations are associated with markedly lower cancer risks than MLH1 or MSH2 mutations, and these risks do not increase appreciably until after the age of 40 years.
Journal ArticleDOI
Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations
Sunil R. Lakhani,Jocelyne Jacquemier,John P. Sloane,Barry A. Gusterson,Thomas J. Anderson,Marc J. van de Vijver,Linda M. Farid,Deon J. Venter,A C Antoniou,Amy Storfer-Isser,Elizabeth Smyth,C. Michael Steel,Neva E. Haites,Rodney J. Scott,David E. Goldgar,Susan L. Neuhausen,Peter A. Daly,Wilma Ormiston,Ross McManus,Siegfried Scherneck,Bruce A.J. Ponder,Debbie Ford,Julian Peto,Dominique Stoppa-Lyonnet,Yves-Jean Bignon,J. P. Struewing,Nigel K. Spurr,D. Timothy Bishop,J. G. M. Klijn,Peter Devilee,Cornelisse J. Cornelisse,Christine Lasset,Gilbert M. Lenoir,Rosa B. Barkardottir,Valgurdur Egilsson,Ute Hamann,Jenny Chang-Claude,Hagay Sobol,Barbara L. Weber,Michael R. Stratton,Douglas F. Easton +40 more
TL;DR: Key features of the histologic phenotypes of breast cancers in carriers of mutant BRCA1 and BRCa2 genes are identified and this information may improve the classification of breast cancer in individuals with a family history of the disease and may ultimately aid in the clinical management of patients.
Journal ArticleDOI
Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype
Sunil R. Lakhani,Jorge S. Reis-Filho,L G Fulford,Frédérique Penault-Llorca,Marc van der Vijver,Suzanne Parry,Timothy Bishop,Javier Benitez,Rivas C,Yves-Jean Bignon,Jenny Chang-Claude,Ute Hamann,Cees J. Cornelisse,Peter Devilee,Matthias W. Beckmann,Carolin Nestle-Krämling,Peter A. Daly,Neva E. Haites,Jenny Varley,Fiona Lalloo,G Evans,Christine Maugard,Hanne Meijers-Heijboer,Jan G. M. Klijn,Edith Olah,Barry A. Gusterson,Silvana Pilotti,Paolo Radice,Siegfried Scherneck,Hagay Sobol,Jocelyne Jacquemier,Teresa Wagner,Julian Peto,Michael R. Stratton,Lesley McGuffog,Douglas F. Easton +35 more
TL;DR: The use of cytokeratin staining in combination with ER and morphology provides a more accurate predictor of BRCA1 mutation status than previously available, that may be useful in selecting patients for BRCa1 mutation testing.
Journal ArticleDOI
Mutation Spectrum and Genotype-Phenotype Analyses in Cowden Disease and Bannayan-Zonana Syndrome, Two Hamartoma Syndromes With Germline PTEN Mutation
Deborah J. Marsh,Valérie Coulon,Kathryn L. Lunetta,Philippe Rocca-Serra,Patricia L. M. Dahia,Zimu Zheng,Danny Liaw,Stacey Caron,Bernadette Duboué,Albert Y. Lin,Anne Louise Richardson,Jean Marie Bonnetblanc,Jean Marie Bressieux,Agnés Cabarrot-Moreau,Agnès Chompret,Liliane Demange,Rosalind A. Eeles,Alan M. Yahanda,Eric R. Fearon,Jean Pierre Fricker,Robert J. Gorlin,Shirley Hodgson,Susan Huson,Didier Lacombe,Frédéric Leprat,Sylvie Odent,Claude Toulouse,Olufunmilayo I. Olopade,Hagay Sobol,Sigrid Tishler,C. Geoffrey Woods,Bruce G. Robinson,H. Christian Weber,Ramon Parsons,Monica Peacocke,Michel Longy,Charis Eng,Charis Eng +37 more
TL;DR: There appeared to be an interdependent association between mutations upstream and within the PTPase core motif, the core motif containing the majority of missense mutations, and the involvement of all major organ systems (central nervous system, thyroid, breast, skin and gastrointestinal tract).