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Ah-Ng Tony Kong
Researcher at Rutgers University
Publications - 283
Citations - 22162
Ah-Ng Tony Kong is an academic researcher from Rutgers University. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 77, co-authored 264 publications receiving 19549 citations. Previous affiliations of Ah-Ng Tony Kong include Thomas Jefferson University & University of Illinois at Chicago.
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Induction of phase I, II and III drug metabolism/transport by xenobiotics
TL;DR: Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs introduced into the human body, and play crucial roles in response to many polycyclic aromatic hydrocarbon receptors and excretion.
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Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis
TL;DR: In vivo and in vitro data generated from the laboratory suggest that many dietary compounds can differentially regulate Nrf2-mediated antioxidant/anti-inflammatory signaling pathways as the first line defense or induce apoptosis once the cells have been damaged.
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Nrf2-Deficient Mice Have an Increased Susceptibility to Dextran Sulfate Sodium–Induced Colitis
TL;DR: The data suggests that Nrf2 could play an important role in protecting intestinal integrity, through regulation of proinflammatory cytokines and induction of phase II detoxifying enzymes.
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Antioxidants and oxidants regulated signal transduction pathways.
Edward D. Owuor,Ah-Ng Tony Kong +1 more
TL;DR: A model is proposed, that at low concentrations, these compounds activate MAPK pathway leading to activation of Nrf2 and ARE with subsequent induction of phase II and other defensive genes which protect cells against toxic insults thereby enhancing cell survival, a beneficial homeostatic response.
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An Update on Current Therapeutic Drugs Treating COVID-19.
Renyi Wu,Lujing Wang,Hsiao-Chen Dina Kuo,Ahmad Shannar,Rebecca Peter,Pochung Jordan Chou,Shanyi Li,Rasika Hudlikar,Xia Liu,Xia Liu,Zhigang Liu,George J. Poiani,George J. Poiani,Louis F. Amorosa,Luigi Brunetti,Luigi Brunetti,Ah-Ng Tony Kong +16 more
TL;DR: It is hoped that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2.