Ahmad Aldossary

TL;DR: Findings show that LPRs can modulate the activity of ENaC and this approach might be promising as co-adjuvant therapy for cystic fibrosis.

TL;DR: Nanoparticle-mediated delivery of ENaCsiRNA to ALI cultures corrected aspects of the mucociliary defect in human CF cells and offers effective delivery and silencing in vivo.

TL;DR: Novel nanovesicle complexes derived from giant unilamellar vesicle precursors comprising self-assembling mixtures of the nanovesicles, plasmid DNA or siRNA and targeting peptide ligands allow for the specific targeted enhancement of nucleic acid delivery with improved biosafety over liposomal formulations and represent a promising tool to improve the arsenal of safe, non-viral vectors to deliver therapeutic cargos in a variety of disorders.

TL;DR: The development of drug-loaded nanofibers containing nifedipine and atorvastatin calcium can be a potential buccal delivery system for geriatric patients' convenience.

TL;DR: RTN formulations can achieve specific tumor‐targeting, with minimal clearance by the liver and so enable delivery of tumor-targeted siRNA therapeutics, and are shown to be RGD peptide‐dependent indicating integrin‐mediated uptake.