M
Martin Attwood
Researcher at University of Oxford
Publications - 8
Citations - 350
Martin Attwood is an academic researcher from University of Oxford. The author has contributed to research in topics: Ribosomal protein & RNA splicing. The author has an hindex of 5, co-authored 6 publications receiving 269 citations. Previous affiliations of Martin Attwood include UCL Institute of Child Health.
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Journal ArticleDOI
Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells
Hamid Dolatshad,Andrea Pellagatti,Marta Fernandez-Mercado,Bon Ham Yip,Luca Malcovati,Martin Attwood,Bartlomiej P Przychodzen,Natasha Sahgal,Alexander Kanapin,Helen Lockstone,L Scifo,Peter Vandenberghe,Elli Papaemmanuil,Christopher W.J. Smith,Peter J. Campbell,Seishi Ogawa,Jaroslaw P. Maciejewski,Mario Cazzola,Kienan I. Savage,Jacqueline Boultwood +19 more
TL;DR: The data indicate that SF3B1 has a critical role in MDS by affecting the expression and splicing of genes involved in specific cellular processes/pathways, many of which are relevant to the known RARS pathophysiology, suggesting a causal link.
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A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism
Nahuel A. Paolini,Martin Attwood,Samuel B. Sondalle,Carolina Marques dos Santos Vieira,Anita M. van Adrichem,Franca di Summa,Marie-Françoise O'Donohue,Pierre-Emmanuel Gleizes,Swaksha Rachuri,Joseph Briggs,Roman Fischer,Peter J. Ratcliffe,Marcin W. Wlodarski,Riekelt H. Houtkooper,Marieke von Lindern,Taco W. Kuijpers,Jonathan D. Dinman,Susan J. Baserga,Matthew E. Cockman,Alyson W. MacInnes +19 more
TL;DR: A ribosomopathy linked to uS12 is described and mechanistic distinctions between RP gene mutations driving hematopoietic disease and those resulting in developmental disorders are revealed.
Journal ArticleDOI
Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis.
Maria Manunta,Aristides D. Tagalakis,Martin Attwood,Martin Attwood,Ahmad Aldossary,Josephine Barnes,Mustafa M. Munye,Alexander Weng,Alexander Weng,Robin J. McAnulty,Stephen L. Hart +10 more
TL;DR: Findings show that LPRs can modulate the activity of ENaC and this approach might be promising as co-adjuvant therapy for cystic fibrosis.
Journal ArticleDOI
Erratum: Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells (Leukemia (2015) 29 (1092-1103) 10.1038/leu.2014.331)
Hamid Dolatshad,Andrea Pellagatti,Marta Fernandez-Mercado,Bon Ham Yip,Luca Malcovati,Martin Attwood,Bartlomiej P Przychodzen,Natasha Sahgal,Alexander Kanapin,Helen Lockstone,L Scifo,Peter Vandenberghe,Elli Papaemmanuil,Christopher W.J. Smith,Peter J. Campbell,Seishi Ogawa,Jaroslaw P. Maciejewski,Mario Cazzola,Kienan I. Savage,Jacqueline Boultwood +19 more
TL;DR: The authors would like to add the following to the Acknowledgements section: AP and JB acknowledge support by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre Programme.
Journal ArticleDOI
Activation of the mTOR signaling pathway by L-leucine in 5q-syndrome and other RPS14-deficient erythroblasts
Bon Ham Yip,Chaitanya Vuppusetty,Martin Attwood,A.A.N. Giagounidis,Ulrich Germing,A A Lamikanra,David J. Roberts,Jaroslaw P. Maciejewski,Peter Vandenberghe,Christina Mecucci,J. S. Wainscoat,Andrea Pellagatti,Jacqueline Boultwood +12 more
TL;DR: Activation of the mTOR signaling pathway by L -leucine in 5q- syndrome and other RPS14-deficient erythroblasts is inhibited and cell death is reported in these patients.