A
Ahmad M. Khalil
Researcher at Case Western Reserve University
Publications - 55
Citations - 10167
Ahmad M. Khalil is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Regulation of gene expression & Gene. The author has an hindex of 23, co-authored 51 publications receiving 9214 citations. Previous affiliations of Ahmad M. Khalil include Scripps Research Institute & University of Florida.
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Journal ArticleDOI
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
Ahmad M. Khalil,Mitchell Guttman,Maite Huarte,Manuel Garber,Arjun Raj,Dianali Rivea Morales,Kelly Thomas,Aviva Presser,Bradley E. Bernstein,Alexander van Oudenaarden,Aviv Regev,Eric S. Lander,John L. Rinn +12 more
TL;DR: A model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression is proposed, and it is shown that siRNA-mediated depletion of certain linc RNAs associated with PRC2 leads to changes in gene expression.
Journal ArticleDOI
A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
Maite Huarte,Mitchell Guttman,Mitchell Guttman,David M. Feldser,Manuel Garber,Magdalena J. Koziol,Magdalena J. Koziol,Daniela Kenzelmann-Broz,Ahmad M. Khalil,Ahmad M. Khalil,Or Zuk,Ido Amit,Michal Rabani,Laura D. Attardi,Aviv Regev,Aviv Regev,Eric S. Lander,Eric S. Lander,Eric S. Lander,Tyler Jacks,John L. Rinn,John L. Rinn +21 more
TL;DR: A model whereby transcription factors activate lincRNAs that serve as key repressors by physically associating with repressive complexes and modulate their localization to sets of previously active genes is proposed.
A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
Maite Huarte,Mitchell Guttman,Mitchell Guttman,David M. Feldser,Manuel Garber,Magdalena J. Koziol,Magdalena J. Koziol,Daniela Kenzelmann-Broz,Ahmad M. Khalil,Ahmad M. Khalil,Or Zuk,Ido Amit,Michal Rabani,Laura D. Attardi,Aviv Regev,Aviv Regev,Eric S. Lander,Eric S. Lander,Eric S. Lander,Tyler Jacks,John L. Rinn,John L. Rinn +21 more
TL;DR: In this paper, the identification of lincRNAs (lincRNA-p21) that serve as a repressor in p53-dependent transcriptional responses was reported, and the observed transcriptional repression was mediated through the physical association with hnRNP-K at repressed genes and regulation of p53 mediates apoptosis.
Journal ArticleDOI
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase
Mohammad Ali Faghihi,Mohammad Ali Faghihi,Farzaneh Modarresi,Ahmad M. Khalil,Douglas E. Wood,Barbara G. Sahagan,Todd E. Morgan,Caleb E. Finch,Georges St. Laurent,Georges St. Laurent,Paul J. Kenny,Claes Wahlestedt +11 more
TL;DR: It is reported that a long noncoding RNA is directly implicated in the increased abundance of Aβ 1–42 in Alzheimer's disease.
Journal ArticleDOI
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs
TL;DR: Recent advances in understanding the biology of lncRNAs are discussed and avenues of investigation are proposed that may lead to fundamental new insights into their functions and mechanisms of action.