Ahmed M. El Kerdawy

TL;DR: Increasing the hydrophobic interaction was accomplished by extending the anilinophthalazine scaffold with a substituted phenyl moiety through an uriedo linker which should give this extension the flexibility required to accommodate itself deeply into theHydrophobic back pocket of the VEGFR-2 active site.

TL;DR: Inhibition of angiogenesis through inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2) has been applied in cancer therapy because of its important role in promoting cancer growth and metastasis and structure-activity relationship was inferred for future optimization.

TL;DR: The interaction energies between an argon atom and the dihalogens Br2, BrCl, and BrF have been investigated using frozen core CCSD(T)(fc)/aug-cc-pVQZ calculations as reference values for other levels of theory, and the newly developed EXXRPA+@dRPA functional represents a systematic improvement on EXxRPA-@EXX.

TL;DR: Motivated by the potential anticancer activity of both coumarin and 2-aminothiazole nuclei, a new set of thiazol-2-yl hydrazono-chromen-1-one analogs were efficiently synthesized aiming to obtain novel hybrids with potential cytotoxic activity.

TL;DR: A hybridization strategy was adopted to combine the binding features of the non-selective COX inhibitor "sulindac" and the selective COX-2 inhibitor "celecoxib" with that of licofelone and a celecoxib pyridone analogue to design new series of pyrazole sulfonamide derivatives which, by design, should possess dual COx-2/5-LOX inhibitory activity.