A
Ahmed M. Mehdi
Researcher at University of Queensland
Publications - 39
Citations - 931
Ahmed M. Mehdi is an academic researcher from University of Queensland. The author has contributed to research in topics: T cell & Medicine. The author has an hindex of 10, co-authored 30 publications receiving 782 citations. Previous affiliations of Ahmed M. Mehdi include University of Engineering and Technology, Lahore & Princess Alexandra Hospital.
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Journal ArticleDOI
Molecular basis for specificity of nuclear import and prediction of nuclear localization
Mary Marfori,Andrew V. Mynott,Jonathan Ellis,Ahmed M. Mehdi,Neil F. W. Saunders,Paul M. G. Curmi,Jade K. Forwood,Mikael Bodén,Bostjan Kobe,Bostjan Kobe +9 more
TL;DR: In this paper, the authors review the current understanding of the molecular determinants of the specificity of nuclear import, focusing on the importin-α•cargo recognition, as well as the currently available databases and predictive tools relevant to nuclear localization.
Journal ArticleDOI
Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients.
Helen Benham,Helen Benham,Hendrik J. Nel,Soi Cheng Law,Ahmed M. Mehdi,Shayna E. A. Street,Nishta Ramnoruth,H. Pahau,Bernett Lee,Jennifer Hwee Kwoon Ng,Marion E. G. Brunck,Claire Hyde,Leendert A. Trouw,Nadine L. Dudek,Anthony W. Purcell,Brendan O'Sullivan,John E. Connolly,Sanjoy K. Paul,Kim-Anh Lê Cao,Ranjeny Thomas +19 more
TL;DR: It is found that HLA risk genotype–positive RA patients had reduced numbers of effector T cells and decreased production of proinflammatory cytokines compared with untreated RA patient controls, and the therapy was safe and did not induce disease flares.
Journal ArticleDOI
IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota
Linda Rehaume,Nicholas Matigian,Ahmed M. Mehdi,Nancy Lachner,Kate L Bowerman,Joshua Daly,Kim-Anh Lê Cao,Philip Hugenholtz,Ranjeny Thomas,Ranjeny Thomas +9 more
TL;DR: Dysbiosis in SKG mice reflects human SpA and is IL- 23p19 dependent, and in genetically susceptible hosts, IL-23p19 favours outgrowth of SpA-associated pathobionts and reduces support for homeostatic-inducing microbiota.
Journal ArticleDOI
Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation
Gergely Róna,Máté Borsos,Jonathan Ellis,Ahmed M. Mehdi,Mary Christie,Zsuzsanna Környei,Máté Neubrandt,Judit Tóth,Zoltán Bozóky,László Buday,Emília Madarász,Mikael Bodén,Bostjan Kobe,Beáta G. Vértessy +13 more
TL;DR: It is shown that the NLS-adjacent phosphorylation by Cdk1 of human dUTPase, an enzyme essential for genomic integrity, results in dynamic cell cycle-dependent distribution of the protein.
Journal ArticleDOI
A probabilistic model of nuclear import of proteins
TL;DR: A probabilistic model is introduced that explicitly recognizes a variety of nuclear localization signals, and integrates relevant amino acid sequence and interaction data for any candidate nuclear protein, and accurately predicts whether a protein is imported into the nucleus.