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Neil F. W. Saunders
Researcher at Commonwealth Scientific and Industrial Research Organisation
Publications - 38
Citations - 2700
Neil F. W. Saunders is an academic researcher from Commonwealth Scientific and Industrial Research Organisation. The author has contributed to research in topics: Methanococcoides burtonii & Paracoccus denitrificans. The author has an hindex of 23, co-authored 38 publications receiving 2555 citations. Previous affiliations of Neil F. W. Saunders include University of Oxford & University of Edinburgh.
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Journal ArticleDOI
Molecular basis for specificity of nuclear import and prediction of nuclear localization
Mary Marfori,Andrew V. Mynott,Jonathan Ellis,Ahmed M. Mehdi,Neil F. W. Saunders,Paul M. G. Curmi,Jade K. Forwood,Mikael Bodén,Bostjan Kobe,Bostjan Kobe +9 more
TL;DR: In this paper, the authors review the current understanding of the molecular determinants of the specificity of nuclear import, focusing on the importin-α•cargo recognition, as well as the currently available databases and predictive tools relevant to nuclear localization.
Journal ArticleDOI
Discovering Sequence Motifs with Arbitrary Insertions and Deletions
TL;DR: Gapped Local Alignment of Motifs is especially promising for short protein motifs, and it should improve the ability to identify the protein cleavage sites, interaction sites, post-translational modification attachment sites, etc., that underlie much of biology.
Journal ArticleDOI
Haem-ligand switching during catalysis in crystals of a nitrogen-cycle enzyme.
Pamela A. Williams,Pamela A. Williams,Vilmos Fülöp,Elspeth F. Garman,Neil F. W. Saunders,Stuart J. Ferguson,Janos Hajdu,Janos Hajdu +7 more
TL;DR: The results show how redox energy can be switched into conformational energy within a haem protein within aHaem protein during catalysis.
Journal ArticleDOI
Mechanisms of Thermal Adaptation Revealed From the Genomes of the Antarctic Archaea Methanogenium frigidum and Methanococcoides burtonii
Neil F. W. Saunders,Torsten Thomas,Paul M. G. Curmi,John S. Mattick,Elizabeth Kuczek,Rob Slade,John Davis,Peter D. Franzmann,David Boone,Karl Rusterholtz,Robert A. Feldman,Chris Gates,Shellie R. Bench,Kevin R. Sowers,Kristen Kadner,Andrea Aerts,Paramvir S. Dehal,Chris Detter,Tijana Glavina,Susan Lucas,Paul G. Richardson,Frank W. Larimer,Loren Hauser,Miriam Land,Ricardo Cavicchioli +24 more
TL;DR: Comparative genomics revealed trends in amino acid and tRNA composition, and structural features of proteins from cold-adapted Archaea, and indicated that GC content is the major factor influencing tRNA stability in hyperthermophiles, but not in the psychrophiles, mesophiles or moderate thermophiles
Journal ArticleDOI
A panel of genes methylated with high frequency in colorectal cancer
Susan M. Mitchell,Jason P. Ross,Horace R. Drew,Thu Ho,Glenn S. Brown,Neil F. W. Saunders,Konsta Duesing,Michael Buckley,Robert Dunne,Iain Beetson,Keith N. Rand,Aidan McEvoy,Melissa L. Thomas,Rohan Baker,David Wattchow,Graeme P. Young,Trevor Lockett,Susanne K. Pedersen,Lawrence C. LaPointe,Peter L. Molloy +19 more
TL;DR: This study characterised a panel of 23 genes that show elevated DNA methylation in >50% of CRC tissue relative to non-neoplastic tissue and identifies 42 candidate genes for evaluation asDNA methylation biomarkers for blood-based diagnostic markers.