A
Ahmed M. Metwaly
Researcher at Al-Azhar University
Publications - 97
Citations - 1918
Ahmed M. Metwaly is an academic researcher from Al-Azhar University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 17, co-authored 51 publications receiving 682 citations. Previous affiliations of Ahmed M. Metwaly include Liaoning University of Traditional Chinese Medicine & University of Alabama.
Papers
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Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers.
Hazem A. Mahdy,Mohammed K. Ibrahim,Ahmed M. Metwaly,Amany Belal,Ahmed B.M. Mehany,Kamal M. El-Gamal,Abdou El-Sharkawy,Mostafa A. Elhendawy,Mohamed M. Radwan,Mahmoud A. ElSohly,Ibrahim H. Eissa +10 more
TL;DR: In vivo antitumor activities of the synthesized quinazoline-based derivatives revealed that compounds 30 and 31 possessed significant tumor growth inhibition effect, and it is said that VEGFR-2 inhibition confers the reported cytotoxic activities.
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Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the h ACE2 Receptor.
Ahmed A. Al-Karmalawy,Mohammed A. Dahab,Ahmed M. Metwaly,Sameh S. Elhady,Eslam B. Elkaeed,Ibrahim H. Eissa,Khaled M. Darwish +6 more
TL;DR: In this paper, the authors considered drug repurposing as an attractive approach that can facilitate the drug discovery process by reusing existing pharmaceuticals to treat illnesses other than their primary indications.
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Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects.
TL;DR: This review article is an attempt to illustrate different methods of preparation of black ginseng, major chemical changes of saponins and other constituents after steaming as well as the reported biological activities ofblack ginsENG, its major saponin and other metabolites.
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Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors
Mohamed-Kamal Ibrahim,Mohammed S Taghour,Ahmed M. Metwaly,Amany Belal,Ahmed B.M. Mehany,Mostafa A. Elhendawy,Mohamed M. Radwan,Abdelrahman M. Yassin,Nehal M. El-Deeb,Elsayed E. Hafez,Mahmoud A. ElSohly,Ibrahim H. Eissa +11 more
TL;DR: It was concluded that DNA binding and/or Topo II inhibition may contribute to the observed cytotoxicity of the synthesized compounds.
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Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of quinazolin-4(3H)-one derivatives as potential PPARγ and SUR agonists.
Mohamed K. Ibrahim,Ibrahim H. Eissa,Mohamed S Alesawy,Ahmed M. Metwaly,Mohamed M. Radwan,Mahmoud A. ElSohly +5 more
TL;DR: A series of novel quinazoline-4(3H)-one-sulfonylurea hybrids were designed and synthesized as dual PPARγ and SUR agonists, evaluating their in vivo anti-hyperglycemic activities against STZ-induced hyperglycemic rats and their in vitro binding affinities and insulin-secreting abilities.